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Diclofenac sodium

Catalog No. T1555 CAS 15307-79-6

Synonyms: GP 45840

Diclofenac sodium (GP 45840) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.

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Diclofenac sodium, CAS 15307-79-6

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500 mg	In stock	$ 45.00

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Purity: 99.89%

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Description	Diclofenac sodium (GP 45840) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
Targets&IC50	COX-2:200 nM, COX-1:60 nM
In vitro	Diclofenac inhibits Wnt/beta-catenin signaling without altering the level of beta-catenin protein and reduces the expression of beta-catenin/TCF-dependent genes. Diclofenac induces the degradation of IkappaBalpha, which increases free nuclear factor kappaB (NF-kappaB) in colon cancer cells. [1] Diclofenac suppresses both fast tetrodotoxin-sensitive (TTX-S) and the slow tetrodotoxin-resistant (TTX-R) sodium currents in a dose-dependent manner. Diclofenac produces shifts of the steady-state inactivation curves in the hyperpolarizing direction in both types of sodium currents in a dose-dependent manner. Diclofenac may bind to sodium channels with a greater affinity when they are in the inactivated state than when they are in the resting state. [2] Diclofenac results in a severe accumulation of protein in the tubular cells (so called hyaline droplet degeneration), macrophage infiltration and structural alterations (dilation, vesiculation) of the endoplasmic reticulum (ER) in the proximal and distal renal tubules of kidney. Diclofenac also results in shortening of podocytes and their retraction from the basal lamina, a thickening of the basal lamina, the formation of desmosomes, and necrosis of endothelial cells in the renal corpuscles of kidney. [3]
In vivo	Diclofenac (0.01 to 0.2 mM) stimulates state-4 respiration and slightly inhibits state 3 in rats, decreasing the respiratory control ratio, while the membrane potential is decreased or collapsed (depending on the drug concentration). [4]

Synonyms	GP 45840
Molecular Weight	318.13
Formula	C14H10Cl2NNaO2
CAS No.	15307-79-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 31.8 mg/mL (100 mM)

H2O: 15.9 mg/mL (50 mM)

References and Literature

1. Kirchheiner J, et al. Br J Clin Pharmacol. 2003 Jan;55(1):51-61.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Inhibitor Library Anti-Cancer Clinical Compound Library Apoptosis Compound Library Clinical Compound Library Pediatric Drug Library FDA-Approved & Pharmacopeia Drug Library

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Keywords

Diclofenac sodium 15307-79-6 Apoptosis Immunology/Inflammation Neuroscience COX ovine cascade CHO anti-inflammatory GP 45840 Diclofenac COX-1 Inhibitor NSCs COX-2 inhibit neural cells Cyclooxygenase GP-45840 GP45840 caspase stem inhibitor

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