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Dynasore

Catalog No. T1848   CAS 304448-55-3
Synonyms: Dynamin Inhibitor I

Dynasore (Dynamin Inhibitor I), a cell-permeable chemical, can reversibly and non-competitivity inhibit GTPase activity of dynamin 1/2 (IC50: 15 μM in a cell-free assay). It also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Dynasore Chemical Structure
Dynasore, CAS 304448-55-3
Pack Size Availability Price/USD Quantity
5 mg In stock $ 45.00
10 mg In stock $ 72.00
25 mg In stock $ 143.00
50 mg In stock $ 272.00
100 mg In stock $ 393.00
200 mg In stock $ 589.00
500 mg In stock $ 929.00
1 mL * 10 mM (in DMSO) In stock $ 79.00
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Purity: 99.89%
Purity: 99.22%
Purity: 95.85%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Dynasore (Dynamin Inhibitor I), a cell-permeable chemical, can reversibly and non-competitivity inhibit GTPase activity of dynamin 1/2 (IC50: 15 μM in a cell-free assay). It also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase.
Targets&IC50 Dynamin1/2:15 μM
In vivo Dynasore ameliorates the motor dysfunction greatly at 3, 7, and 10 days after SCI in rats. Dynasore markedly enhances motor function which may be through inhibiting the activation of neuronal mitochondrial apoptotic pathway and astrocytic proliferation in rats after SCI[4].
Kinase Assay RIP1 kinase assay: Phosphorylation of RIP1 requires its kinase activity. Expression constructs of FLAGtagged wild-type (WT) or a kinase-inactive point mutant of RIP1 (K45M) are are transfected into 293T cells and RIP1 kinase assay is performed as described in the Methods in the presence of [γ-32P]ATP for 30 min at 30℃. Samples are subjected to SDS-PAGE and RIP1 band is visualized by autoradiography. Relative intensities of radioactive bands are quantified and are shown (ratio) in this and all other autoradiographs. In parallel to kinase reactions, a sample of beads is subjected to western blot analysis using anti-RIP1 antibody to ensure equal protein amounts in kinase reactions.
Cell Research Mouse ventricular myocytes are isolated from male adult C6/Black mouse. Cardiomyocytes subjects to 2 hours of drug treatment followed by oxidative stress (30 μM Water2 for 35 min). For ATP supplement experiments, the cells are treated with 3 mM ATP for 30 min before exposure to Water2. Cardiomyocyte survival and viability are analyzed by trypan blue exclusion (TBE) assay[3].
Synonyms Dynamin Inhibitor I
Molecular Weight 322.31
Formula C18H14N2O4
CAS No. 304448-55-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 1.6 mg/mL (5 mM)

DMSO: 32.2 mg/mL (100 mM)

TargetMolReferences and Literature

1. Macia E, et al. Dev Cell, 2006, 10(6), 839-850. 2. Newton AJ, et al. Proc Natl Acad Sci USA, 2006, 103(47), 17955-17960. 3. Abban CY, et al. Am J Ther, 2008, 15(4), 304-311. 4. Li G, et al. Dynasore Improves Motor Function Recovery via Inhibition of Neuronal Apoptosis and Astrocytic Proliferation after Spinal Cord Injury in Rats. Mol Neurobiol. 2016 Nov 7. 5. Xu L L, Zhang X, Jiang Z Y, et al. Molecular similarity guided optimization of novel Nrf2 activators with 1, 2, 4-oxadiazole core[J]. Bioorganic & medicinal chemistry. 2016, 24(16): 3540-3547. 6. Wang X, Chen Q Z, Zan Y X, et al. . Exosomal miR‐145‐5p derived from orthohantavirus‐infected endothelial cells inhibits HTNV infection. The FASEB Journal. 2020, 34(10): 13809-13825. 7. Zhong B, Shi D, Wu F, et al. Dynasore suppresses cell proliferation, migration, and invasion and enhances the antitumor capacity of cisplatin via STAT3 pathway in osteosarcoma[J]. Cell death & disease. 2019, 10(10): 1-16. 8. Jiang K, Hou X, Tan T, et al. Scavenger receptor-C acts as a receptor for Bacillus thuringiensis vegetative insecticidal protein Vip3Aa and mediates the internalization of Vip3Aa via endocytosis[J]. PLoS pathogens. 2018 Oct 4;14(10):e1007347. 9. Zhang Y, Xue W, Zhang W, et al. Histone methyltransferase G9a protects against acute liver injury through GSTP1. Cell Death & Differentiation. 2019: 1-16.

TargetMolCitations

1. Zhao Z, Wei Z, Zheng J, et al.Hepatitis B virus promotes its own replication by enhancing RAB5A-mediated dual activation of endosomal and autophagic vesicle pathways: RAB5A promotes HBV replication.Emerging Microbes & Infections.2023 (just-accepted): 2261556. 2. Zhu X, Zhao Y, Liu Y, et al.Macrophages release IL11-containing filopodial tip vesicles and contribute to renal interstitial inflammation.Cell Communication and Signaling.2023, 21(1): 1-17. 3. Wang T, Wang L, Li W, et al.Fowl adenovirus serotype 4 enters leghorn male hepatocellular cells via the clathrin-mediated endocytosis pathway.Veterinary Research.2023, 54(1): 1-14. 4. Xu L L, Zhang X, Jiang Z Y, et al. Molecular similarity guided optimization of novel Nrf2 activators with 1, 2, 4-oxadiazole core. Bioorganic & medicinal chemistry. 2016, 24(16): 3540-3547. 5. Jiang K, Hou X, Tan T, et al. Scavenger receptor-C acts as a receptor for Bacillus thuringiensis vegetative insecticidal protein Vip3Aa and mediates the internalization of Vip3Aa via endocytosis. PLoS Pathogens. 2018 Oct 4;14(10):e1007347 6. Zhang Y, Xue W, Zhang W, et al. Histone methyltransferase G9a protects against acute liver injury through GSTP1. Cell Death & Differentiation. 2020, 27(4): 1243-1258 7. Zhong B, Shi D, Wu F, et al. Dynasore suppresses cell proliferation, migration, and invasion and enhances the antitumor capacity of cisplatin via STAT3 pathway in osteosarcoma. Cell Death & Disease. 2019, 10(10): 1-16 8. Lu J Y, Huang W T, Zhou K, et al. Microbial Lipopeptide Supramolecular Self‐Assemblies as a Methuosis‐Like Cell Death Inducer with In Vivo Antitumor Activity. Small. 2021: 2104034. 9. Wang X, Chen Q Z, Zan Y X, et al.  Exosomal miR‐145‐5p derived from orthohantavirus‐infected endothelial cells inhibits HTNV infection. The FASEB Journal. 2020, 34(10): 13809-13825. 10. Xia T, Liu Z, Du Y, et al.Bifunctional iRGD-Exo-DOX crosses the blood-brain barrier to target central nervous system lymphoma.Biochemical Pharmacology.2024: 116138.

Related compound libraries

This product is contained In the following compound libraries:
Highly Selective Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Inhibitor Library Cytoskeletal Signaling Pathway Compound Library Autophagy Compound Library Anti-Viral Compound Library Human Metabolite Library Mitochondria-Targeted Compound Library Anti-Aging Compound Library

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Keywords

Dynasore 304448-55-3 Autophagy Cytoskeletal Signaling Microbiology/Virology Virus Protease Dynamin HSV Inhibitor Herpes simplex virus inhibit Dynamin Inhibitor I inhibitor

 

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