Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Elacestrant (RAD1901) with IC50s of 48 and 870 nM for ERα and ERβ, respectively.Elacestrant is an orally available selective estrogen receptor degrader .
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 147.00 | |
5 mg | In stock | $ 347.00 | |
10 mg | In stock | $ 497.00 | |
25 mg | In stock | $ 793.00 | |
50 mg | In stock | $ 1,130.00 | |
100 mg | In stock | $ 1,520.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 388.00 |
Description | Elacestrant (RAD1901) with IC50s of 48 and 870 nM for ERα and ERβ, respectively.Elacestrant is an orally available selective estrogen receptor degrader . |
Targets&IC50 | ERβ:870 nM , ERα:48 nM |
In vitro | RAD1901 treatment exhibits dose-dependent inhibition of ERα expression, with an EC50 of 0.6 nM.?Treatment of ER-positive MCF-7 cells with E2 results in a potent and dose-dependent increase in proliferation, with an EC50 of 4 pM.?Treatment of cells with RAD1901 in the presence of 10 pM E2 resultsin a dose-dependent decrease in proliferation, with an IC50 value of 4.2 nM.RAD1901 selectively binds to and degrades the ER and is a potent antagonist of ER-positive breast cancer cell proliferation.? |
In vivo | RAD1901 produces a robust and profound inhibition of tumor growth in MCF-7 xenograft models.?RAD1901 preserves ovariectomy-induced bone loss and preventes the uterotropic effects of E2.RAD1901-treated animals survived longer than those treated with either control or fulvestrant.? |
Synonyms | RAD1901 |
Molecular Weight | 458.63 |
Formula | C30H38N2O2 |
CAS No. | 722533-56-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (130.82 mM)
You can also refer to dose conversion for different animals. More
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Elacestrant 722533-56-4 Endocrinology/Hormones Estrogen Receptor/ERR Estrogen/progestogen Receptor inhibit Inhibitor RAD1901 RAD 1901 RAD-1901 inhibitor