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Griseofulvin

Griseofulvin
Griseofulvin (Fulvicin) is an antifungal agent used in the treatment of TINEA infections.
Catalog No. T1382Cas No. 126-07-8
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Purity:95.83%
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Griseofulvin

Catalog No. T1382Cas No. 126-07-8
Griseofulvin (Fulvicin) is an antifungal agent used in the treatment of TINEA infections.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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500 mg$41In Stock
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Product Introduction

Bioactivity
Description
Griseofulvin (Fulvicin) is an antifungal agent used in the treatment of TINEA infections.
In vitro
Griseofulvin exhibits effective anti-infective activity in vivo. When administered in conjunction with nocodazole (5 mg/kg), Griseofulvin significantly enhances the efficacy of nocodazole, resulting in the cessation of tumor growth.
In vivo
In vitro tests have demonstrated that the minimum inhibitory concentration (MIC) of Griseofulvin against various dermatophytes ranges between 0.14 to 0.6 µg/mL. Griseofulvin's primary mechanism of action on cellular mitosis is the disassembly of spindle microtubules. Additionally, Griseofulvin has the capacity to induce chromosomal structural abnormalities in mammalian cells. It is effective in combating different types of skin fungi, including species from the genera Microsporum, Trichophyton, and Epidermophyton. However, it is not sensitive to other fungi, such as Scopulariopsis and Hendersonula, and has almost no effect on yeasts.
Cell Research
The cells (5× 103/mL) are incubated in triplicate in a 96-well plate in the presence or absence of indicated concentration of Griseofulvin in a final volume of 0.2 mL for different time intervals at 37 ℃. Thereafter, 20 μL MTT solution (5 mg/mL in PBS) is added to each well. After a 2-hour incubation at 37 ℃, 0.1 mL lysis buffer (20% SDS, 50% dimethylformamide) is added, incubation is continued overnight at 37 ℃, and then the optical density at 570 nm is measured by plate reader. (Only for Reference)
AliasFulvicin, Amudane, Grisactin
Chemical Properties
Molecular Weight352.77
FormulaC17H17ClO6
Cas No.126-07-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 60 mg/mL (170.08 mM), Sonication is recommended.
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8347 mL14.1735 mL28.3471 mL141.7354 mL
5 mM0.5669 mL2.8347 mL5.6694 mL28.3471 mL
10 mM0.2835 mL1.4174 mL2.8347 mL14.1735 mL
20 mM0.1417 mL0.7087 mL1.4174 mL7.0868 mL
50 mM0.0567 mL0.2835 mL0.5669 mL2.8347 mL
100 mM0.0283 mL0.1417 mL0.2835 mL1.4174 mL

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