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HLCL-61 hydrochloride
HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.
Catalog No. T6857Cas No. 1158279-20-9
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Purity:99.91%
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HLCL-61 hydrochloride
Catalog No. T6857Cas No. 1158279-20-9
HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $30 | In Stock | |
| 10 mg | $43 | In Stock | |
| 25 mg | $73 | In Stock | |
| 50 mg | $118 | In Stock | |
| 100 mg | $223 | In Stock | |
| 200 mg | $313 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $31 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia. |
| Targets&IC50 | PRMT5:16.74 μM |
| In vitro | HLCL-61 shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members. HLCL-61 shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples.Treatment of AML cell lines (MV4-11 and THP-1) and primary blasts with HLCL-61 also results in a decrease of cell viability. HLCL-61 is also effective in promoting apoptosis in MV4-11 and THP-1 cells after 48 h[1]. |
| Cell Research | CD11b expression is tested by flow cytometry on cells treated with DMSO or HLCL-61 (25 and 50 μM) for 48 h.(Only for Reference) |
| Alias | HLCL61, HLCL-61 HCL |
| Molecular Weight | 380.91 |
| Formula | C23H24N2O·ClH |
| Cas No. | 1158279-20-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 15 mg/mL (32.7 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 50 mg/mL (131.26 mM), Heating is recommended.  | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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