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IOWH-032

Catalog No. T2486 CAS 1191252-49-9

Synonyms: IOWH032, IOWH 032

IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.

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IOWH-032, CAS 1191252-49-9

Pack Size	Availability	Price/USD
10 mg	In stock	$ 54.00
25 mg	In stock	$ 94.00
50 mg	In stock	$ 146.00
100 mg	In stock	$ 228.00
1 mL * 10 mM (in DMSO)	In stock	$ 40.00

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Purity: 100%

Purity: 99%

Purity: 98.92%

Purity: 98%

Biological Description

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Description	IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.
Targets&IC50	CFTR:1.01 μM
In vitro	In a closed-system mouse model, IOWH032 effectively inhibits the secretions induced by cholera toxin. Moreover, in a rat model with the cecum removed, IOWH032 (5 mg/kg) suppresses the excretion of waste.
In vivo	In T84-CFTR cells (IC50=6.87 μM), IOWH032 effectively inhibits CFTR activity.
Kinase Assay	Enzyme assays are performed using a homogeneous time-resolved fluorescence assay with recombinant epitope tagged kinase domains (JAK1, 837-1142; JAK2, 828-1132; JAK3, 718-1124; Tyk2, 873-1187) or full-length enzyme (cMET and Chk2) and peptide substrate. Each enzyme reaction is performed with or without test compound (11-point dilution), JAK, cMET, or Chk2 enzyme, 500 nM (100 nM for Chk2) peptide, ATP (at the Km specific for each kinase or 1 mM), and 2.0% DMSO in assay buffer. The calculated IC50 value is the compound concentration required for inhibition of 50% of the fluorescent signal. Additional kinase assays are performed at Cerep using standard conditions at 200 nM. Enzymes tested included: Abl, Akt1, AurA, AurB, CDC2, CDK2, CDK4, CHK2, c-kit, EGFR, EphB4, ERK1, ERK2, FLT-1, HER2, IGF1R, IKKα, IKKβ, JNK1, Lck, MEK1, p38α, p70S6K, PKA, PKCα, Src, and ZAP70[1].

Synonyms	IOWH032, IOWH 032
Molecular Weight	545.18
Formula	C22H15Br2N3O4
CAS No.	1191252-49-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 93 mg/mL (170.6 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Drug Repurposing Compound Library Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Fibrosis Compound Library Clinical Compound Library ReFRAME Related Library Target-Focused Phenotypic Screening Library Anti-Cancer Compound Library NO PAINS Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

IOWH-032 1191252-49-9 Autophagy Membrane transporter/Ion channel CFTR inhibit SARS-CoV Inhibitor Cystic fibrosis transmembrane conductance regulator SARS coronavirus anti-diarrheal CFBE41o- WT cells IOWH032 ACE-2 IOWH 032 inhibitor

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