Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KH7 is a soluble inhibitor of adenylyl cyclase (sAC)-specific. It has IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays. KH7 is also a cAMP inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 37.00 | |
2 mg | In stock | $ 50.00 | |
5 mg | In stock | $ 82.00 | |
10 mg | In stock | $ 132.00 | |
25 mg | In stock | $ 265.00 | |
50 mg | In stock | Inquiry | |
1 mL * 10 mM (in DMSO) | In stock | $ 91.00 |
Description | KH7 is a soluble inhibitor of adenylyl cyclase (sAC)-specific. It has IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays. KH7 is also a cAMP inhibitor. |
Targets&IC50 | sAC:3-10 μM |
In vitro | KH7 prevents the generation of CaSF. KH7 (10 μM) blocks this capacitation-induced cAMP increase. At higher concentrations (50 μM), 5- to 10-fold above its IC50 but still selective for sAC relative to tmACs, KH7 resulted in a significant decrease in the basal cAMP accumulation in sperm regardless of the incubation medium. The myocytes exert a negative inotropic effect (NIE) of approximately 20%, in the presence of KH7. This suggesting that sAC is involved in the normal generation of basal cardiac contractility [1,2]. |
Molecular Weight | 419.3 |
Formula | C17H15BrN4O2S |
CAS No. | 330676-02-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 0.1 mg/mL (insoluble)
DMSO: 100 mg/mL (238.49 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
KH7 330676-02-3 GPCR/G Protein Neuroscience AChR cAMP inhibit KH-7 Adenylate Cyclase Adenylyl cyclase Inhibitor KH 7 inhibitor