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L-745870 trihydrochloride

Catalog No. T22904 CAS 866021-03-6

Synonyms: L-745,870 trihydrochloride

L-745870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist.

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L-745870 trihydrochloride Chemical Structure

L-745870 trihydrochloride, CAS 866021-03-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 68.00
2 mg	In stock	$ 98.00
5 mg	In stock	$ 148.00
10 mg	In stock	$ 212.00
25 mg	In stock	$ 487.00
50 mg	In stock	$ 696.00
100 mg	In stock	$ 987.00
500 mg	In stock	$ 1,980.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	L-745870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist.
Targets&IC50	D2 receptor:960 nM (Ki), D4 receptor:4.3 nM (Ki), D3 receptor:2300 nM (Ki)
In vivo	L-745870 has favorable pharmacokinetic properties in both rats and monkeys, and shows excellent brain permeability and a high brain-to-plasma ratio in rats [1]. L-745870 (10 mg/kg p.o.) at 30 mg/kg caused mild sedation and extrapyramidal motor symptoms, especially bradykinesia, following oral administration to squirrel monkeys. Lower doses of L-745870 had no apparent behavioral effects in monkeys [1].

Synonyms	L-745,870 trihydrochloride
Molecular Weight	436.21
Formula	C18H22Cl4N4
CAS No.	866021-03-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 40 mg/mL

References and Literature

1. Bristow LJ, et al. Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist. Trends Pharmacol Sci. 1997 Jun;18(6):186-8. 2. Kulagowski JJ, et al. 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. J Med Chem. 1996 May 10;39(10):1941-2.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library GPCR Compound Library Anti-Neurodegenerative Disease Compound Library Neuronal Signaling Compound Library Serotonin Receptor-Targeted Compound Library Neurotransmitter Receptor Compound Library Orally Active Compound Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Parkinson's Disease Compound Library

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Related compounds with same targets

Tetrahydroberberine Oxolinic acid L-745870 hydrochloride Brexpiprazole S-oxide D8 NEO 376 Minaprine Zuclopenthixol Pramipexole

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Keywords

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