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LMP744 hydrochloride

Catalog No. T11872L   CAS 308246-57-3
Synonyms: NSC706744 hydrochloride, MJ-III65 hydrochloride

LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. 

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LMP744 hydrochloride Chemical Structure
LMP744 hydrochloride, CAS 308246-57-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 122.00
5 mg In stock $ 239.00
10 mg In stock $ 372.00
25 mg In stock $ 623.00
50 mg In stock $ 888.00
100 mg In stock $ 1,220.00
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Purity: 98.44%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. 
In vitro LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle[2].The GI50 value of LMP744 for NCI60 cells is 0.1 μM[2].
In vivo LMP744 ?(10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity[1].
Synonyms NSC706744 hydrochloride, MJ-III65 hydrochloride
Molecular Weight 488.92
Formula C24H25ClN2O7
CAS No. 308246-57-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5.56 mg/mL (11.37 mM), sonification is recommended.

TargetMolReferences and Literature

1. Antony S, et al. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Mol Pharmacol. 2005 Feb;67(2):523-30. 2. Antony S, et al. Bisindenoisoquinoline bis-1,3-{( 5,6-dihydro-5,11-diketo-11H-indeno [1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity. Mol Pharmacol. 2006 Sep;70(3):1109-20.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Inhibitor Library Anti-Cancer Compound Library Bioactive Compound Library DNA Damage & Repair Compound Library Bioactive Compounds Library Max Clinical Compound Library

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Keywords

LMP744 hydrochloride 308246-57-3 DNA Damage/DNA Repair Topoisomerase NSC706744 hydrochloride Inhibitor NSC 706744 LMP744 inhibit LMP-744 LMP-744 hydrochloride NSC-706744 Hydrochloride NSC706744 LMP744 Hydrochloride NSC-706744 LMP 744 Hydrochloride LMP-744 Hydrochloride MJ-III65 Hydrochloride MJ-III65 MJ-III65 hydrochloride LMP 744 NSC 706744 Hydrochloride NSC706744 Hydrochloride inhibitor

 

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