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Latrepirdine dihydrochloride

Catalog No. T6562 CAS 97657-92-6

Synonyms: Dimebolin, Latrepirdine 2HCl, Dimebolin dihydrochloride, Latrepirdine

Latrepirdine is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug.

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Latrepirdine dihydrochloride, CAS 97657-92-6

Pack Size	Availability	Price/USD
5 mg	5 days	$ 43.00
10 mg	5 days	$ 86.00
1 mL * 10 mM (in DMSO)	5 days	$ 48.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Latrepirdine is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug.
In vitro	Latrepirdine increases succinate dehydrogenase activity (MTT-assay), mitochondrial membrane potential (DeltaPsim), and cellular ATP levels in primary mouse cortical neurons and human neuroblastoma cells (SH-SY5Y). Latrepirdine enhances mitochondrial function both in the absence and presence of stress and Dimebon-treated cells are partially protected to maintain cell viability. [1] Latrepirdine leads to enhanced mTOR- and Atg5-dependent autophagy in cultured mammalian cells. [2] latrepirdine stimulates MTOR- and ATG5-dependent autophagy, leading to the reduction of intracellular levels of APP metabolites, including Aβ in cultured cells. [3] Latrepirdine stimulates the degradation of α-syn in differentiated SH-SY5Y neurons, and in mouse brain following chronic administration, in parallel with elevation of the levels of markers of autophagic activity. [4] Latrepirdine increases intracellular ATP levels and glucose transporter 3 translocation to the plasma membrane in primary neuron. [5]
In vivo	Latrepirdine treatment of TgCRND8 transgenic mice is associated with improved learning behavior and with a reduction in accumulation of Aβ42 and α-synuclein. [2] Latrepirdine administration results in increased levels of the biomarkers thought to correlate with autophagy activation in the brains of TgCRND8 (APP K670M, N671L, V717F) or wild-type mice, and that treatment is associated with abrogation of behavioral deficit, reduction in Aβ neuropathology, and prevention of autophagic failure among TgCRND8 mice. [3]

Synonyms	Dimebolin, Latrepirdine 2HCl, Dimebolin dihydrochloride, Latrepirdine
Molecular Weight	392.37
Formula	C21H25N3·2HCl
CAS No.	97657-92-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 39.2 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Zhang S, et al. J Alzheimers Dis, 2010, 21(2), 389-402. 2. Steele JW, et al. Mol Psychiatry, 2013, 18(8), 889-897. 3. Lenasi H, et al. Cardiovasc Res, 2003, 59(4), 844-853. 4. Steele JW, et al. Mol Psychiatry, 2013, 18(8), 882-888. 5. Weisová P, et al. Transl Psychiatry, 2013, 3, e317.

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Keywords

Latrepirdine dihydrochloride 97657-92-6 Autophagy GPCR/G Protein Immunology/Inflammation Neuroscience 5-HT Receptor Beta Amyloid Adrenergic Receptor GluR Histamine Receptor Serotonin Receptor Dimebolin 5-hydroxytryptamine Receptor Latrepirdine 2HCl Amyloid-β Inhibitor Dimebolin dihydrochloride inhibit Abeta β-amyloid peptide Latrepirdine Beta Receptor inhibitor

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