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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $30 | In Stock | |
1 mL x 10 mM (in DMSO) | $48 | In Stock |
Description | Latrepirdine dihydrochloride (Dimebolin dihydrochloride) is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug. |
In vitro | Latrepirdine increases succinate dehydrogenase activity (MTT-assay), mitochondrial membrane potential (DeltaPsim), and cellular ATP levels in primary mouse cortical neurons and human neuroblastoma cells (SH-SY5Y). Latrepirdine enhances mitochondrial function both in the absence and presence of stress and Dimebon-treated cells are partially protected to maintain cell viability. [1] Latrepirdine leads to enhanced mTOR- and Atg5-dependent autophagy in cultured mammalian cells. [2] latrepirdine stimulates MTOR- and ATG5-dependent autophagy, leading to the reduction of intracellular levels of APP metabolites, including Aβ in cultured cells. [3] Latrepirdine stimulates the degradation of α-syn in differentiated SH-SY5Y neurons, and in mouse brain following chronic administration, in parallel with elevation of the levels of markers of autophagic activity. [4] Latrepirdine increases intracellular ATP levels and glucose transporter 3 translocation to the plasma membrane in primary neuron. [5] |
In vivo | Latrepirdine treatment of TgCRND8 transgenic mice is linked to improved learning behavior and reduced accumulation of Aβ42 and α-synuclein. [2] Latrepirdine administration results in increased levels of biomarkers associated with autophagy activation in the brains of TgCRND8 (APP K670M, N671L, V717F) or wild-type mice, and is also associated with behavioral improvement, reduced Aβ neuropathology, and prevention of autophagic failure in TgCRND8 mice. [3] |
Alias | Dimebolin dihydrochloride, Latrepirdine, Latrepirdine 2HCl, Dimebolin |
Molecular Weight | 392.37 |
Formula | C21H25N3·2HCl |
Cas No. | 97657-92-6 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 39.2 mg/mL (100 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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