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MSDC 0160

Catalog No. T2607 CAS 146062-49-9

Synonyms: CAY10415, Mitoglitazone, MSDC0160, MSDC-0160

MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.

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MSDC 0160, CAS 146062-49-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 30.00
2 mg	In stock	$ 43.00
5 mg	In stock	$ 70.00
10 mg	In stock	$ 101.00
25 mg	In stock	$ 156.00
50 mg	In stock	$ 207.00
100 mg	In stock	$ 369.00
1 mL * 10 mM (in DMSO)	In stock	$ 75.00

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Purity: 99.53%

Purity: 99.45%

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Description	MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.
In vitro	In the KKAy mouse model of diabetes, MSDC-0160 (100 mg/kg, p.o.) significantly enhanced insulin sensitivity by substantially reducing the levels of insulin and glucose in the circulatory system.
In vivo	Within the insulin and IGF-1 signaling pathways, MSDC-0160 reduces resistance and restores IGF-1-induced phosphorylation of AKt and GSK-3. When used in conjunction with IGF-1 and 8 mM glucose, MSDC-0160 boosts the expression of specific genes within β-cells, including insulin, pdx1, nkx6.1, and nkx2.2, while maintaining insulin content without affecting glucose-induced insulin secretion. Additionally, MSDC-0160 promotes the differentiation of human β-cells and decreases the expression of apoptosis markers.
Kinase Assay	Measurement of activities of autophosphorylated/non-autophosphorylate CaMKII: CaMKII activity is measured utilizing syntideII as a substrate. Purified CaMKII is pre-incubated in the assay mixture ( 35 mM Hepes-Na ( pH 8.0 ), 10 mM MgC12, 0.5 μM CaM, 5 μM ATP, 1 mM CaCl2 or 1 mM EGTA, total 25 μL) at 30 °C for 2 minutes. After this pre-incubation, the protein substrate/radioactive ATP mixture is added to the same test tube and the preparation is further incubated at 30 °C, for 5 minutes ( final assay condition; 35 mM Hepes-Na (pH 8.0), 10 mM MgCl2, 0.125 μM CaCl2, 20 μM syntideII, 11.25 μM [ γ-32P] ATP, 10 % DMSO and indicated concentrations of KN-93, supplemented with 0.25 mM CaCl2 and 2 mM EGTA (for autophosphorylated samples) or 0.25 mM EGTA and 2 mM CaCl2 (for nonautophosphorylated samples ), total 100 μL ). The reaction is terminated by adding of 25 μL of 100 % ( w/v ) ice-cold TCA. After centrifugation, 80 μL of the supernatant is applied to phosphocellulose paper. The filters are then washed with 75 mM H3P04 for 15 min with continuous agitation. After 4-cycles of washing, the radioactivity retains on the filter paper is quantified in a liquid scintillation counter.

Synonyms	CAY10415, Mitoglitazone, MSDC0160, MSDC-0160
Molecular Weight	370.42
Formula	C19H18N2O4S
CAS No.	146062-49-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 37 mg/mL (100 mM)

References and Literature

1. Rohatgi N, et al. PLoS One. 2013, 8(5), e62012. 2. Bolten CW, et al. Gene Regul Syst Bio. 2007, 1, 73-82.

Citations

1. Qi Y, Hu M, Qiu Y, et al.Mitoglitazone ameliorates renal ischemia/reperfusion injury by inhibiting ferroptosis via targeting mitoNEET.Toxicology and Applied Pharmacology.2023: 116440.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Kinase Inhibitor Library Tyrosine Kinase Inhibitor Library Anti-Cancer Compound Library Anti-Lung Cancer Compound Library Anti-Cardiovascular Disease Compound Library Clinical Compound Library

Related Products

Related compounds with same targets

GIP (3-42), human acetate HNMPA GSK1904529A PQ401 ALK-IN-1 Lenaldekar Kaempferitrin NVP-TAE 226

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Keywords

MSDC 0160 146062-49-9 Metabolism Others Tyrosine Kinase/Adaptors IGF-1R Mitochondrial Metabolism mTOT CAY10415 antidiabetic pyruvate Mitoglitazone CAY 10415 MPC insulin Insulin Receptor thiazolidinedione MSDC0160 inhibit Inhibitor sensitizer neuroprotective carrier CAY-10415 MSDC-0160 Alzheimer mitochondrial inhibitor

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