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NUCC-390

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Purity:98.18%

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COA HNMR HPLC

NUCC-390

Catalog No. T12269Cas No. 1060524-97-1

NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100. This compound facilitates nerve functional recovery following neurodegeneration in vivo.

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Pack Size	Price	Availability
1 mg	$151	In Stock
5 mg	$318	In Stock
10 mg	$498	In Stock
25 mg	$812	In Stock
50 mg	$1,130	In Stock
100 mg	$1,520	In Stock
500 mg	$2,970	In Stock
1 mL x 10 mM (in DMSO)	$377	In Stock

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Product Introduction

Bioactivity

Description	NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100. This compound facilitates nerve functional recovery following neurodegeneration in vivo.
In vitro	NUCC-390 (10 μM) produces strong (Ca)i response, but this effect can be blocked by the known potent and selective CXCR4 antagonist AMD3100. NUCC-390 (10 μM; pre-treatment 30 mins) leads to increased levels of pERK, it has the capability of stimulating signaling activity downstream of CXCR4 receptors. NUCC-390 (10 μM; 2 hours) can induce CXCR4 receptor internalization, and non-treated cells exhibit some diffuse expression of CXCR4-YFP throughout the cytosol and clear expression in the cell membrane in HEK cells[1]. NUCC-390 (0-1.25 μM; 24 hours) boosts axonal growth in cultured cerebellar granule neurons (CGNs) via CXCR4[2].
In vivo	NUCC-390 (hind limb injection; 3.2 mg/kg; twice daily; 3 days) contributes to the functional and anatomical recovery of the neuromuscular junction (NMJ) following an acute nerve terminal damage by α-LTx in CD-1 mice[2].

Chemical Properties

Molecular Weight	395.54
Formula	C23H33N5O
Cas No.	1060524-97-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (151.69 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5282 mL	12.6409 mL	25.2819 mL	126.4095 mL
5 mM	0.5056 mL	2.5282 mL	5.0564 mL	25.2819 mL
10 mM	0.2528 mL	1.2641 mL	2.5282 mL	12.6409 mL
20 mM	0.1264 mL	0.6320 mL	1.2641 mL	6.3205 mL
50 mM	0.0506 mL	0.2528 mL	0.5056 mL	2.5282 mL
100 mM	0.0253 mL	0.1264 mL	0.2528 mL	1.2641 mL

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