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Nirmatrelvir
Catalog No. T9351Cas No. 2628280-40-8
PF-07321332 is a potent and orally active inhibitor of SARS-CoV 3C-like protease (3CLPRO) .
Nirmatrelvir
Catalog No. T9351Cas No. 2628280-40-8
PF-07321332 is a potent and orally active inhibitor of SARS-CoV 3C-like protease (3CLPRO) .
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $53 | In Stock | |
| 2 mg | $75 | In Stock | |
| 5 mg | $123 | In Stock | |
| 10 mg | $197 | In Stock | |
| 25 mg | $349 | In Stock | |
| 50 mg | $539 | In Stock | |
| 100 mg | $697 | In Stock | |
| 200 mg | $995 | In Stock | |
| 500 mg | $1,490 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $136 | In Stock |
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Purity:99.51%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PF-07321332 is a potent and orally active inhibitor of SARS-CoV 3C-like protease (3CLPRO) . |
| In vitro | PF-07321332 is a promising oral antiviral clinical candidate with well-established anti-SARS-CoV-2 activity in vitro. |
| In vivo | METHODS: To assay in vivo antiviral activity, Nirmatrelvir (20 mg/kg, 2% DMSO + 20% sulfobutylether-β-cyclodextrin in 0.9% saline) and Molnupiravir (20 mg/kg) were orally administered to SARS-CoV-2 infected K18-hACE2 transgenic mice twice daily for five days. RESULTS: In lethally infected mice, the combination of Nirmatrelvir and Molnupiravir demonstrated severe inhibition of SARS-CoV-2 replication in the lungs and brain and synergistically improved survival by up to 80%. 36% survival was achieved with Nirmatrelvir alone, and 43% with Molnupiravir alone. [3] |
| Molecular Weight | 499.53 |
| Formula | C23H32F3N5O4 |
| Cas No. | 2628280-40-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (90.08 mM), Sonication is recommended.  10% DMSO+40% PEG300+5% Tween 80+45% Saline: 13 mg/mL (26.02 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
10% DMSO+40% PEG300+5% Tween 80+45% Saline/DMSO
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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