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Novobiocin Sodium

Catalog No. T0974 CAS 1476-53-5

Synonyms: Albamycinsodium, Cathomycin, Albamycin

Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin.

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Novobiocin Sodium, CAS 1476-53-5

Pack Size	Availability	Price/USD
25 mg	In stock	$ 42.00
50 mg	In stock	$ 59.00
100 mg	In stock	$ 87.00
1 mL * 10 mM (in DMSO)	In stock	$ 40.00

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Purity: 99.28%

Purity: 99.1%

Purity: 99.07%

Purity: 99%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin.
Targets&IC50	HSP90:700 μM (IC50)
In vitro	Novobiocin also interacts with Hsp90, altering the affinity of the chaperone for geldanamycin and radicicol and causing in vitro and in vivo depletion of key regulatory Hsp90-dependent kinases including v-Src, Raf-1, and p185(ErbB2). Novobiocin interferes with association of the co-chaperones Hsc70 and p23 with Hsp90. [1] Novobiocin specifically inhibits the maturation of the heme-regulated eIF2alpha kinase (HRI) in a concentration-dependent manner. Novobiocin induces the dissociation of Hsp90 and Cdc37 from immature HRI, while the Hsp90 cochaperones p23, FKBP52, and protein phosphatase 5 remained associated with immature HRI. [2] Novobiocin causes morphological and biochemical changes which lead to induction of cell death exhibiting characteristic features of metazoan apoptosis. [3] Novobiocin, a HSP90 inhibitor, could decrease the expression of SMYD3 and dose dependently inhibit the proliferation and migration of MDA-MB-231 human breast cancer cells. Novobiocin can inhibit the migration of breast cancer cells and such event may involve the downregulation of SMYD3. [4] Novobiocin, an aminocoumarin antibiotic, interferes with heat shock protein 90 and hypoxia inducible factor dependent gene expression and thus compromises cell survival. Novobiocin (500 礛) results in a significant increase of [Ca(2+)]i, decrease of forward scatter, increase of annexin-V-binding and enhances ceramide formation. Novobiocin stimulates eryptosis, an effect at least in part due to entry of extracellular Ca(2+) and formation of ceramide. [5]

Synonyms	Albamycinsodium, Cathomycin, Albamycin
Molecular Weight	634.61
Formula	C31H35N2NaO11
CAS No.	1476-53-5

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (47.27 mM)

References and Literature

1. Marcu MG, et al. J Biol Chem, 2000, 275(47), 37181-37186. 2. Yun BG, et al. Biochemistry,2004, 43(25), 8217-8229. 3. Singh G, et al. Mol Biochem Parasitol,2005, 141(1), 57-69. 4. Luo XG, et al. IUBMB Life,2010, 62(3), 194-199. 5. Lupescu A, et al. Cell Physiol Biochem,2014, 33(3), 670-680.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Anti-Cancer Drug Library Membrane Protein-targeted Compound Library Microbial Natural Product Library Covalent Natural Product Library Autophagy Compound Library Covalent Inhibitor Library Anti-Tumor Natural Product Library FDA-Approved Drug Library

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Keywords

Novobiocin Sodium 1476-53-5 Autophagy DNA Damage/DNA Repair Membrane transporter/Ion channel Microbiology/Virology Antibacterial Topoisomerase ABC Antibiotic DNA gyrase Potassium Channel DNA/RNA Synthesis pneumococcal K562 orally active Mutz-2 Albamycinsodium Apoptosis DNA interstrand cross-links cells Bacterial anti-infection HL60 Orthopoxvirus Novobiocin Cathomycin Albamycin Inhibitor Heat shock proteins HSP inhibit anti-orthopoxvirus inhibitor

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