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Oleandrin

Catalog No. T5S0890   CAS 465-16-7
Synonyms: Neriostene, Folinerin, Foliandrin

1. Oleandrin (Folinerin), the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional levels. 2. Oleandrin are known to inhibit the Na, K-ATPase pump, resulting in a consequent increase in calcium influx in heart muscle. 3. Oleandrin has stronger anti-proliferative activity in undifferentiated CaCO-2 cells (IC50, 8.25 nM) , causes an autophagic cell death and altered ERK phosphorylation in undifferentiated.

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Oleandrin Chemical Structure
Oleandrin, CAS 465-16-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 98.00
2 mg In stock $ 147.00
5 mg In stock $ 289.00
10 mg In stock $ 463.00
25 mg In stock $ 763.00
50 mg In stock $ 1,070.00
100 mg In stock $ 1,430.00
500 mg In stock $ 2,890.00
1 mL * 10 mM (in DMSO) In stock $ 367.00
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Purity: 99.94%
Purity: 99.31%
Purity: 98.07%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 1. Oleandrin (Folinerin), the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional levels. 2. Oleandrin are known to inhibit the Na, K-ATPase pump, resulting in a consequent increase in calcium influx in heart muscle. 3. Oleandrin has stronger anti-proliferative activity in undifferentiated CaCO-2 cells (IC50, 8.25 nM) , causes an autophagic cell death and altered ERK phosphorylation in undifferentiated.
Targets&IC50 Na+, K+-ATPase:620 nM (IC50)
Source
Synonyms Neriostene, Folinerin, Foliandrin
Molecular Weight 576.72
Formula C32H48O9
CAS No. 465-16-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: Soluble

Pyridine, Methanol, etc.: Soluble

DMSO: 60 mg/ml (104.04 mM)

TargetMolReferences and Literature

1. Raviprakash N , Manna S K . Short-term exposure to oleandrin enhances responses to IL-8 by increasing cell surface IL-8 receptors[J]. British Journal of Pharmacology, 2014, 171(14):3339-3351. 2. Pan L, Zhang Y, Zhao W, et al. The cardiac glycoside oleandrin induces apoptosis in human colon cancer cells via the mitochondrial pathway[J]. Cancer Chemotherapy and Pharmacology. 2017 Jul;80(1):91-100.

TargetMolCitations

1. Pan L, Zhang Y, Zhao W, et al. The cardiac glycoside oleandrin induces apoptosis in human colon cancer cells via the mitochondrial pathway. Cancer Chemotherapy and Pharmacology. 2017 Jul;80(1):91-100

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Tumor Natural Product Library Covalent Inhibitor Library Toxic Compound Library Natural Product Library Inhibitor Library Ion Channel Inhibitor Library Human Metabolite Library

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Keywords

Oleandrin 465-16-7 Apoptosis Membrane transporter/Ion channel Potassium Channel ATPase Sodium Channel Neriostene PBI-05204 Folinerin Na+/K+ ATPase PBI 05204 Inhibitor PBI05204 Sodium potassium pump Foliandrin inhibit inhibitor

 

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