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Org-12962

Catalog No. T16401 CAS 132834-56-1

Org-12962 is an effective and selective 5-HT2C receptor agonist pEC50: 7.01). Org-12962 shows antiaversive effects in a rat model of panic-like anxiety. Org-12962 also shows high effacy for the 5-HT2A and 5-HT2B receptors (pEC50s: 6.38 and 6.28, respectively).

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Org-12962, CAS 132834-56-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 41.00
10 mg	In stock	$ 66.00
25 mg	In stock	$ 98.00
50 mg	In stock	$ 138.00
100 mg	In stock	$ 197.00

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Purity: 98.34%

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Description	Org-12962 is an effective and selective 5-HT2C receptor agonist pEC50: 7.01). Org-12962 shows antiaversive effects in a rat model of panic-like anxiety. Org-12962 also shows high effacy for the 5-HT2A and 5-HT2B receptors (pEC50s: 6.38 and 6.28, respectively).
Targets&IC50	5-HT2C receptor:7.01 （pEC50）, 5-HT2A receptor:6.38 （pEC50）, 5-HT2B receptor:6.28 （pEC50）
In vivo	Org-12962 is dissolved or microsuspended in 0.3% v/v Tween 80 in physiological saline (NaCl 0.9%). Org-12962 (intraperitoneal injection; 0.3-3.2 mg/kg) obviously enhances the postinjection frequency thresholds for self-interruption (F3.71=11.40) [1].

Molecular Weight	265.66
Formula	C10H11ClF3N3
CAS No.	132834-56-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225 mg/mL (846.9 mM), Sonication is recommended.

References and Literature

1. Porter RH,et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.Br J Pharmacol. 1999 Sep;128(1):13-20. 2. Jenck F, et al. Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.Eur Neuropsychopharmacol. 1998 Aug;8(3):161-8. 3. Faassen F, et al. Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.Int J Pharm. 2003 Sep 16;263(1-2):113-22.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Membrane Protein-targeted Compound Library Neurotransmitter Receptor Compound Library Neuronal Signaling Compound Library Covalent Inhibitor Library Bioactive Compounds Library Max Anti-Cancer Compound Library ReFRAME Related Library Bioactive Compound Library Antidepressant Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

Org-12962 132834-56-1 GPCR/G Protein Neuroscience 5-HT Receptor Org 12962 Org12962 inhibitor inhibit

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