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Otenzepad
Catalog No. T16411Cas No. 102394-31-0
Alias AF-DX 116
Otenzepad (AF-DX 116) is a selective M2 mAChR antagonist with IC50 values of 386 nM in rat heart and 640 nM in rabbit peripheral lung.
Otenzepad
Catalog No. T16411Alias AF-DX 116Cas No. 102394-31-0
Otenzepad (AF-DX 116) is a selective M2 mAChR antagonist with IC50 values of 386 nM in rat heart and 640 nM in rabbit peripheral lung.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $39 | In Stock | |
| 5 mg | $76 | In Stock | |
| 10 mg | $133 | In Stock | |
| 25 mg | $283 | In Stock | |
| 50 mg | $455 | In Stock | |
| 100 mg | $672 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $84 | In Stock |
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Purity:99.81%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Otenzepad (AF-DX 116) is a selective M2 mAChR antagonist with IC50 values of 386 nM in rat heart and 640 nM in rabbit peripheral lung. |
| Targets&IC50 | M2 mAChR (rat heart):386 nM, M2 mAChR (rabbit peripheral lung):640 nM |
| In vivo | In rats, Otenzepad (2 mg/kg; s.c.) significantly improved retention relative to vehicle controls. Otenzepad (0.5, 1 mg/kg; s.c.) significantly improved win-stay acquisition[1]. In mice, Otenzepad (0.3, 1.0, or 3.0 mg/kg, i.p.) reverses the effects of insulin on memory and potentiates the effects of glucose[2]. |
| Alias | AF-DX 116 |
| Molecular Weight | 421.54 |
| Formula | C24H31N5O2 |
| Cas No. | 102394-31-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 24 mg/mL (56.93 mM), Sonication and heating to 60℃ are recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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