Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 161.00 | |
25 mg | In stock | $ 324.00 | |
50 mg | In stock | $ 537.00 | |
100 mg | In stock | $ 649.00 | |
500 mg | In stock | $ 1,380.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 86.00 |
Description | PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor. |
Targets&IC50 | CSF1R:0.016 µM (IC50), CSF1R:Ki: 5.9 nM |
In vivo | Treated pregnant dams with the CSF1R inhibitor PLX-5622. Approximately 99% of microglia were eliminated by embryonic day 15.5 (E15.5) after pregnant dams were placed on a PLX-5622 diet starting at E3.5. Following microglia depletion, Elevated numbers of apoptotic cells accumulating throughout the developing hypothalamus. Once the PLX-5622 diet was removed, microglia repopulated the postnatal brain within 7?days and did not appear to repopulate from Nestin+?precursors[1]. |
Synonyms | PLX-5622 |
Molecular Weight | 395.41 |
Formula | C21H19F2N5O |
CAS No. | 1303420-67-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 79 mg/mL (199.79 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PLX5622 1303420-67-8 Tyrosine Kinase/Adaptors c-Fms CSF-1R Inhibitor CSF-1 receptor PLX-5622 microglial PLX 5622 CSF1R orally pathology inhibit penetrant preceding brain colony stimulating factor 1 receptor elimination inhibitor