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Paroxetine hydrochloride

Catalog No. T1636   CAS 78246-49-8
Synonyms: Paroxetine HCl, BRL29060 hydrochloride, FG-7051, BRL29060A

Paroxetine hydrochloride (Paroxetine HCl) is a serotonin uptake inhibitor that is effective in the treatment of depression.

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Paroxetine hydrochloride Chemical Structure
Paroxetine hydrochloride, CAS 78246-49-8
Pack Size Availability Price/USD Quantity
25 mg In stock $ 45.00
50 mg In stock $ 54.00
100 mg In stock $ 78.00
200 mg In stock $ 112.00
500 mg In stock $ 153.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.91%
Purity: 99.61%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Paroxetine hydrochloride (Paroxetine HCl) is a serotonin uptake inhibitor that is effective in the treatment of depression.
Targets&IC50 GRK2:14 μM
Cell Research Paroxetine is dissolved in DMSO. Cell viability is determined by the tetrazolium salt 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. BV2 and primary microglial cells are initially seeded into 96-well plates at a density of 1×104 cells/well and 5×104 cells/well, respectively. Following treatment, MTT (5 mg/mL in PBS) is added to each well and incubated at 37°C for four hours. The resulting formazan crystals are dissolved in dimethylsulfoxide (DMSO). The optical density is measured at 570 nm, and results are expressed as a percentage of surviving cells compared with the control.
Synonyms Paroxetine HCl, BRL29060 hydrochloride, FG-7051, BRL29060A
Molecular Weight 365.826
Formula C19H21ClFNO3
CAS No. 78246-49-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mg/mL (27.33 mM)

Ethanol: 35 mg/mL (95.67 mM)

DMSO: 73 mg/mL (199.54 mM)

TargetMolReferences and Literature

1. Le Poul E, et al. Naunyn Schmiedebergs Arch Pharmacol, 1995, 352(2), 141-148. 2. von Moltke LL, et al. J Clin Psychopharmacol, 1995, 15(2), 125-131. 3. Thomas DR, et al. Psychopharmacology (Berl), 1987, 93(2), 193-200. 4. Bertelsen KM, et al. Drug Metab Dispos, 2003, 31(3), 289-293. 6. Lassen TR, et al. Effect of paroxetine on left ventricular remodeling in an in vivo rat model of myocardial infarction. Basic Res Cardiol. 2017 May;112(3):26. 7. Waldschmidt HV, et al. Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. J Med Chem. 2017 Apr 13;60(7):3052-3069. 8. Wang K, Gong Q, Zhan Y, et al. Blockage of autophagic flux and induction of mitochondria fragmentation by Paroxetine hydrochloride in lung cancer cells promotes apoptosis via the ROS-MAPK pathway[J]. Frontiers in Cell and Developmental Biology. 2020, 7: 397.

TargetMolCitations

1. Wang K, Gong Q, Zhan Y, et al. Blockage of autophagic flux and induction of mitochondria fragmentation by Paroxetine hydrochloride in lung cancer cells promotes apoptosis via the ROS-MAPK pathway. Frontiers in Cell and Developmental Biology. 2020, 7: 397

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Approved Drug Library Antidepressant Compound Library Drug-induced Liver Injury (DILI) Compound Library Serotonin Receptor-Targeted Compound Library Autophagy Compound Library Fluorochemical Library GPCR Compound Library

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Keywords

Paroxetine hydrochloride 78246-49-8 Autophagy GPCR/G Protein Neuroscience Serotonin Transporter GRK AChR 5-HT Receptor BRL 29060 Hydrochloride Paroxetine Hydrochloride BRL 29060 FG7051 Paroxetine HCl inhibit Paroxetine BRL29060 Hydrochloride SLC6A4 BRL-29060 Hydrochloride BRL29060 FG 7051 Inhibitor SERT BRL29060 hydrochloride BRL-29060 5-HTT FG-7051 BRL29060A inhibitor

 

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