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Phenylbiguanide

Catalog No. T7135   CAS 102-02-3
Synonyms: PBG, N-Phenylbiguanide, 1-Phenylbiguanide

Phenylbiguanide (N-Phenylbiguanide) is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM)

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Phenylbiguanide Chemical Structure
Phenylbiguanide, CAS 102-02-3
Pack Size Availability Price/USD Quantity
50 mg In stock $ 30.00
100 mg In stock $ 39.00
500 mg In stock $ 89.00
1 mL * 10 mM (in DMSO) In stock $ 43.00
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Purity: 99.87%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Phenylbiguanide (N-Phenylbiguanide) is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM)
Targets&IC50 5-HT3:3 μM (EC50)
In vivo Phenylbiguanide (PBG) is a drug known to stimulate cardiopulmonary afferent C-fibres. PBG is injected into the right atrium of the heart in anaesthetised mice and mapped c-Fos expression within specific regions of the central nervous system. Intraatrial injection of PBG produces a reflex cardiorespiratory response including a pronounced bradycardia and a respiratory depression[1].
Synonyms PBG, N-Phenylbiguanide, 1-Phenylbiguanide
Molecular Weight 177.21
Formula C8H11N5
CAS No. 102-02-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 150 mg/mL (846.45 mM)

TargetMolReferences and Literature

1. de Vries A, Paton JF, Lightman SL,et al.Characterisation of c-Fos expression in the central nervous system of mice following right atrial injections of the 5-HT3 receptor agonist phenylbiguanide[J].Auton Neurosci. 2005 Dec 30;123(1-2):62-75. 2. Benuck M , Reith M E A . Dopamine releasing effect of phenylbiguanide in rat striatal slices[J]. Archiv für Experimentelle Pathologie und Pharmakologie, 1992, 345(6):666-672.

Related compound libraries

This product is contained In the following compound libraries:
NO PAINS Compound Library Anti-Neurodegenerative Disease Compound Library Human Metabolite Library Neuronal Signaling Compound Library Bioactive Compounds Library Max Bioactive Compound Library Antidepressant Compound Library Anti-Parkinson's Disease Compound Library Anti-Cancer Compound Library GPCR Compound Library

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Keywords

Phenylbiguanide 102-02-3 GPCR/G Protein Neuroscience 5-HT Receptor 5-hydroxytryptamine Receptor inhibit PBG N-Phenylbiguanide Serotonin Receptor 1-Phenylbiguanide Inhibitor inhibitor

 

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