Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Phenytoin (5,5-Diphenylhydantoin) is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cortex reducing post-tetanic potentiation at synapses. The reduction of potentiation prevents cortical seizure foci spreading to adjacent areas, stabilizing the threshold against hyperexcitability. In addition, this agent appears to reduce sensitivity of muscle spindles to stretch causing muscle relaxation.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 g | In stock | $ 50.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Phenytoin (5,5-Diphenylhydantoin) is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cortex reducing post-tetanic potentiation at synapses. The reduction of potentiation prevents cortical seizure foci spreading to adjacent areas, stabilizing the threshold against hyperexcitability. In addition, this agent appears to reduce sensitivity of muscle spindles to stretch causing muscle relaxation. |
Synonyms | Diphenylhydantoin, 5,5-Diphenylhydantoin |
Molecular Weight | 252.27 |
Formula | C15H12N2O2 |
CAS No. | 57-41-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 11 mg/mL (43.6 mM)
DMSO: 47 mg/mL (186.3 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Phenytoin 57-41-0 Membrane transporter/Ion channel Microbiology/Virology Sodium Channel Virus Protease tumour Voltage-gated metastasis Na channels Na+ channels Inhibitor inhibit breast antiepileptic Diphenylhydantoin 5,5-Diphenylhydantoin Na+ VGSCs inhibitor