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Posatirelin

Catalog No. T34114Cas No. 78664-73-0
Alias RGH-2202, Posatirelinum, BRN-6006446, BRN6006446, BRN 6006446

Posatirelin (BRN6006446) is a synthetic peptide with modulatory activity and neurotrophic effects on monoaminergic and cholinergic systems for the study of vascular dementia.

Posatirelin

Posatirelin

Purity: 98.22%
Catalog No. T34114Alias RGH-2202, Posatirelinum, BRN-6006446, BRN6006446, BRN 6006446Cas No. 78664-73-0
Posatirelin (BRN6006446) is a synthetic peptide with modulatory activity and neurotrophic effects on monoaminergic and cholinergic systems for the study of vascular dementia.
Pack SizePriceAvailabilityQuantity
1 mg$130In Stock
5 mg$320In Stock
10 mg$480In Stock
25 mg$786In Stock
50 mg$1,080In Stock
100 mg$1,480In Stock
500 mg$2,960In Stock
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Purity:98.22%
ee:100%
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Product Introduction

Bioactivity
Description
Posatirelin (BRN6006446) is a synthetic peptide with modulatory activity and neurotrophic effects on monoaminergic and cholinergic systems for the study of vascular dementia.
In vivo
The pharmacokinetics and endocrine effects of a therapeutic dose (10 mg/day) of posatirelin were investigated in healthy elderly subjects. Posatirelin was given once daily by intramuscular injection for 7 days. Pharmacokinetic parameters were estimated using a model-independent approach. The plasma concentrations of free triiodothyronine (FT3), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) and the circadian rhythms of prolactin and cortisol were considered as indicators variables of endocrine response to posatirelin administration. Posatirelin was well tolerated and no significant adverse effects were observed during the study. There were no significant changes in these parameters after multiple-dose administration (day 7). Posatirelin induced a progressive reduction in basal TSH levels and maximum response. There were no significant changes during treatment in the time at which basal levels of FT3 and FT4 occurred, and these levels remained within the normal range throughout the study. The circadian rhythms of cortisol and prolactin were not influenced by posatirelin treatment. The pharmacokinetics of posatirelin were not time-dependent, and the drug did not accumulate after multiple-dose administration. Short-term treatment with posatirelin did not induce clinically relevant endocrine consequences in healthy elderly subjects.[1]
AliasRGH-2202, Posatirelinum, BRN-6006446, BRN6006446, BRN 6006446
Chemical Properties
Molecular Weight352.43
FormulaC17H28N4O4
Cas No.78664-73-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 25 mg/mL (70.94 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8374 mL14.1872 mL28.3744 mL141.8721 mL
5 mM0.5675 mL2.8374 mL5.6749 mL28.3744 mL
10 mM0.2837 mL1.4187 mL2.8374 mL14.1872 mL
20 mM0.1419 mL0.7094 mL1.4187 mL7.0936 mL
50 mM0.0567 mL0.2837 mL0.5675 mL2.8374 mL

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