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Pyroxamide

Catalog No. T7664   CAS 382180-17-8

Pyroxamide is an histone deacetylases (HDACs) inhibitor with antineoplastic properties ( HDAC1;IC50: 0.1-0.2 μM).

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Pyroxamide Chemical Structure
Pyroxamide, CAS 382180-17-8
Pack Size Availability Price/USD Quantity
5 mg In stock $ 43.00
10 mg In stock $ 75.00
25 mg In stock $ 162.00
50 mg In stock $ 279.00
100 mg In stock $ 492.00
1 mL * 10 mM (in DMSO) In stock $ 48.00
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Purity: 98.77%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Pyroxamide is an histone deacetylases (HDACs) inhibitor with antineoplastic properties ( HDAC1;IC50: 0.1-0.2 μM).
Targets&IC50 HDAC1:0.1-0.2 μM
In vitro The activity of pyroxamide as an inhibitor of HDACs.?Pyroxamide inhibited the enzymatic activity of affinity-purified HDAC1 at submicromolar concentrations ?.?The ID50 value for inhibition of HDAC1 activity by pyroxamide was ~100 nm.MEL cells incubated with pyroxamide (4 μm) for 4, 24, or 48 h showed accumulation of acetylated histones H2A, H2B, H3, and H4 .?Cells cultured without the agent had low basal levels of acetylated histones at the same time points[1]
In vivo Pyroxamide may be a useful agent for the treatment of malignancy and that induction of p21/WAF1 in transformed cells by pyroxamide may contribute to the antitumor effects of this agent[1].
Cell Research HDAC1 enzyme assay, ?A MEL cell line expressing the epitope Flag-tagged HDAC1 was generated.?HDAC1-Flag was affinity purified by immunoprecipitation using M2 anti-Flag antibody-coated agarose, followed by elution from the agarose using the Flag peptide.?[3H]acetate-labeled cellular histones were prepared from MEL cells and were used as a substrate for the HDAC activity assay.?Released [3H]acetic acid was quantified by scintillation counting.?For inhibition studies, the enzyme preparations were preincubated with pyroxamide (10 to 100,000 nm) for 30 min at 4°C.[1]
Molecular Weight 265.31
Formula C13H19N3O3
CAS No. 382180-17-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (471.15 mM)

TargetMolReferences and Literature

1. Butler L M , Webb Y , Agus D B , et al. Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase[J]. Clinical Cancer Research, 2001, 7(4):962-970.

TargetMolCitations

1. Chen W, Liao Y, Sun P, et al.Construction of an ER stress-related prognostic signature for predicting prognosis and screening the effective anti-tumor drug in osteosarcoma.Journal of Translational Medicine.2024, 22(1): 1-19.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Bioactive Compound Library Clinical Compound Library Bioactive Compounds Library Max Anti-Pancreatic Cancer Compound Library Epigenetics Compound Library NF-κB Signaling Compound Library Chromatin Modification Compound Library

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Keywords

Pyroxamide 382180-17-8 Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair HDAC HDAC1 inhibit Histone deacetylases leukemia Inhibitor inhibitor

 

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