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SC144

Catalog No. T6207 CAS 895158-95-9

SC144 is an orally active small-molecule gp130 inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

SC144, CAS 895158-95-9

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 68.00
25 mg	In stock	$ 139.00
50 mg	In stock	$ 233.00
100 mg	In stock	$ 392.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 99.85%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SC144 is an orally active small-molecule gp130 inhibitor.
Targets&IC50	Gp130:< 1 μM (Cell assay)
In vitro	SC144 exhibits potent cytotoxicity against a panel of drug-sensitive and drug-resistant cancer cell lines. SC144 shows synergism with both 5-fluorouracil and oxaliplatin when co-treated in colorectal cancer HT29 cells. Pretreatment with SC144 in oxaliplatin-resistant HTOXAR3 cells is more effective than oxaliplatin pretreatment. In addition, the combination of SC144 and paclitaxel exhibited synergism in MDA-MB-435 cells with a schedule-dependent block in cell cycle. [1] SC144 treatment in vitro induces gp130 phosphorylation and deglycosylation, resulting in the downregulation of surface-bound gp130 and the abrogation of gp130-associated Stat3 activation. In addition, SC144 selectively inhibits the downstream signaling activation induced by gp130 substrates, including IL-6 and LIF. Protein expression regulated by the gp130/Stat3 axis in OVCAR-8 cells is also down-regulated after SC144 treatment, including Bcl-2, Bcl-XL, survivin, cyclin D1, MMP-7, gp130 and Ape1/Rel-1. [2]
In vivo	SC144 significantly inhibits tumor growth in a mouse xenograft model of human ovarian cancer via i.p. or p.o. administration. After SC144 treatment for two months, gp130, Bcl-2, Bcl-XL, MMP-7 and Ape1/Ref-1 protein levels are substantially decreased in the tumor site in the treatment group compared with the control group. [2] In an MDA-MB-435 mouse xenograft model, co-administration of SC144 and paclitaxel delays tumor growth in an SC144 dose-dependent manner. Evaluation of the pharmacokinetics of SC144 reveals that intraperitoneal administration of SC144 shows a two-compartmental pharmacokinetics elimination profile that is not observed in the oral dosing. [1]
Cell Research	MTT assay (Only for Reference)

Molecular Weight	322.3
Formula	C16H11FN6O
CAS No.	895158-95-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 27 mg/mL (83.8 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Oshima T, et al. Anticancer Drugs, 2009, 20(5), 312-320. 2. Xu S, et al. Mol Cancer Ther, 2013, 12(6), 937-949.

Citations

1. Guo C, Dong J, Ma Y, et al. LIF and bFGF enhanced chicken primordial follicle activation by Wnt/β-catenin pathway. Theriogenology. 2021

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Immunology/Inflammation Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Apoptosis Compound Library Target-Focused Phenotypic Screening Library NO PAINS Compound Library Anti-Ovarian Cancer Compound Library Orally Active Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SC144 895158-95-9 Apoptosis Immunology/Inflammation Interleukin SC-144 anti-angiogenesis Inhibitor oral inhibit SC 144 arrest translocation ovarian nuclear Interleukin Related phosphorylation cancer cell-cycle inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.