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Sepantronium bromide
Catalog No. T2111Cas No. 781661-94-7
Alias YM155
Sepantronium bromide (YM155) is a small-molecule proapoptotic agent with potential antineoplastic activity.
Sepantronium bromide
Catalog No. T2111Alias YM155Cas No. 781661-94-7
Sepantronium bromide (YM155) is a small-molecule proapoptotic agent with potential antineoplastic activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $33 | In Stock | |
| 5 mg | $50 | In Stock | |
| 10 mg | $72 | In Stock | |
| 25 mg | $151 | In Stock | |
| 50 mg | $270 | In Stock | |
| 100 mg | $441 | In Stock | |
| 500 mg | $980 | In Stock |
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Purity:99.82%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Sepantronium bromide (YM155) is a small-molecule proapoptotic agent with potential antineoplastic activity. |
| Targets&IC50 | Survivin:0.54 nM |
| In vitro | Subcutaneous injection of 3 and 10 mg/kg YM155 into prostate transplantation tumors showed that YM155 completely inhibited the tumor growth of PC-3 with no decrease in weight and no decrease in blood cell count. Moreover, 5 mg/kg YM155 showed 80% tumor inhibition in PC-3 ectopic graft tumors.The combination of YM155 and γ-radiation showed high antitumor activity against H460 or Calu6 xenografts in nude mice. |
| In vivo | Subcutaneous injection of 3 and 10 mg/kg YM155 into prostate transplantation tumors showed that YM155 completely inhibited the tumor growth of PC-3 with no decrease in weight and no decrease in blood cell count. Moreover, 5 mg/kg YM155 showed 80% tumor inhibition in PC-3 ectopic graft tumors.The combination of YM155 and γ-radiation showed high antitumor activity against H460 or Calu6 xenografts in nude mice. |
| Kinase Assay | Promoter-luciferase reporter assay: A 2,767-bp sequence of human survivin gene promoter is isolated from human genomic DNA by PCR using Pyrobest polymerase and the following primers: 5 |
| Cell Research | Cells are seeded in 96-well plates at a density of 5-40 × 103. YM155 is dissolved in DMSO and added to cells for 48 hours. Then the cell count is determined by sulforhodamine B assay. (Only for Reference) |
| Alias | YM155 |
| Molecular Weight | 443.26 |
| Formula | C20H19BrN4O3 |
| Cas No. | 781661-94-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | H2O: 82 mg/mL (185 mM) Ethanol: 6 mg/mL (13.53 mM) DMSO: 4.43 mg/mL (10 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO/Ethanol/H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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