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Sepantronium bromide

Catalog No. T2111   CAS 781661-94-7
Synonyms: YM155

Sepantronium bromide (YM155) is a small-molecule proapoptotic agent with potential antineoplastic activity.

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Sepantronium bromide Chemical Structure
Sepantronium bromide, CAS 781661-94-7
Pack Size Availability Price/USD Quantity
2 mg In stock $ 33.00
5 mg In stock $ 50.00
10 mg In stock $ 72.00
25 mg In stock $ 151.00
50 mg In stock $ 270.00
100 mg In stock $ 441.00
500 mg In stock $ 980.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.82%
Purity: 99.82%
Purity: 99.72%
Purity: 99.68%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Sepantronium bromide (YM155) is a small-molecule proapoptotic agent with potential antineoplastic activity.
Targets&IC50 Survivin:0.54 nM
Kinase Assay Promoter-luciferase reporter assay: A 2,767-bp sequence of human survivin gene promoter is isolated from human genomic DNA by PCR using Pyrobest polymerase and the following primers: 5
Cell Research Cells are seeded in 96-well plates at a density of 5-40 × 103. YM155 is dissolved in DMSO and added to cells for 48 hours. Then the cell count is determined by sulforhodamine B assay. (Only for Reference)
Synonyms YM155
Molecular Weight 443.26
Formula C20H19BrN4O3
CAS No. 781661-94-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 82 mg/mL (185 mM)

Ethanol: 6 mg/mL (13.53 mM)

DMSO: 51 mg/mL (115.1 mM)

TargetMolReferences and Literature

1. Nakahara T, et al. Cancer Res, 2007, 67(17), 82014-8021. 2. Iwasa T, et al. Clin Cancer Res, 2008, 14(20), 6496-6504.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Hematonosis Compound Library ReFRAME Related Library Inhibitor Library Angiogenesis related Compound Library Anti-Breast Cancer Compound Library Anti-COVID-19 Compound Library Anti-Lung Cancer Compound Library

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Keywords

Sepantronium bromide 781661-94-7 Apoptosis Autophagy Survivin inhibit Inhibitor YM-155 Sepantronium YM155 YM 155 Sepantronium Bromide inhibitor

 

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