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Silymarin

Catalog No. T6670 CAS 65666-07-1

Synonyms: Silybin B

Silymarin (Silybin B) (Silybin B) is a polyphenolic flavonoid that extracts from the milk thistle or seeds of Silybum marianum. It is used in the prevention and treatment of liver diseases.

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Silymarin, CAS 65666-07-1

Pack Size	Availability	Price/USD
250 mg	In stock	$ 42.00
500 mg	In stock	$ 62.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Silymarin (Silybin B) (Silybin B) is a polyphenolic flavonoid that extracts from the milk thistle or seeds of Silybum marianum. It is used in the prevention and treatment of liver diseases.
In vitro	Mechanism of Silymarin involves different biochemical reactions, such as stimulation of the rate of ribosomal RNA synthesis by stimulating the transcription of polymerase I and ribosomal RNA genes, blockage of alpha-glycoside loops toxin intake, and protection of cell membranes from free radical-induced damage. Silymarin also displays a substantial protective effect against UVB-induced canceration at different stages, possibly through its strong antioxidant properties.
In vivo	The intravenous injection LD50 of Silymarin is 391.4 mg/kg, 70.1 mg/kg, 142.3 mg/kg for mice, rats, rabbits, respectively.
Source	Natural Products > Asteraceae > Silybum

Synonyms	Silybin B
Molecular Weight	482.44
Formula	C25H22O10
CAS No.	65666-07-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 97 mg/mL (201.06 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 1 mg/mL (2.07 mM)

References and Literature

1. Feher J, et al. Curr Pharm Biotechnol, 2012, 13(1), 210-217. 2. Wellington K, et al. BioDrugs, 2001, 15(7), 465-489. 3. Katiyar SK, et al. J Natl Cancer Inst, 1997, 89(8), 556-566.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Bioactive Compounds Library Max Anti-infective Natural Product Library Anti-Viral Compound Library Orally Active Compound Library

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Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Silymarin 65666-07-1 Microbiology/Virology SARS-CoV thistle angiogenesis Inhibitor Silybin B hepatocellular resistance SARS coronavirus chemopreventive inhibit HCC Milk insulin proliferation carcinoma inhibitor

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