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Silymarin

Catalog No. T6670 CAS 65666-07-1

Synonyms: Silybin B, 水飞蓟素

Silymarin (Silybin B) is a polyphenolic flavonoid that extracts from the milk thistle or seeds of Silybum marianum. It is used in the prevention and treatment of liver diseases.

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Silymarin, CAS 65666-07-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Silymarin (Silybin B) is a polyphenolic flavonoid that extracts from the milk thistle or seeds of Silybum marianum. It is used in the prevention and treatment of liver diseases.
In vitro	Mechanism of Silymarin involves different biochemical reactions, such as stimulation of the rate of ribosomal RNA synthesis by stimulating the transcription of polymerase I and ribosomal RNA genes, blockage of alpha-glycoside loops toxin intake, and protection of cell membranes from free radical-induced damage. Silymarin also displays a substantial protective effect against UVB-induced canceration at different stages, possibly through its strong antioxidant properties.
In vivo	The intravenous injection LD50 of Silymarin is 391.4 mg/kg, 70.1 mg/kg, 142.3 mg/kg for mice, rats, rabbits, respectively.

Synonyms	Silybin B, 水飞蓟素
Molecular Weight	482.441
Formula	C25H22O10
CAS No.	65666-07-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 97 mg/mL (201.06 mM)

H2O: <1 mg/mL

Ethanol: 1 mg/mL (2.07 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Feher J, et al. Curr Pharm Biotechnol, 2012, 13(1), 210-217. 2. Wellington K, et al. BioDrugs, 2001, 15(7), 465-489. 3. Katiyar SK, et al. J Natl Cancer Inst, 1997, 89(8), 556-566.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Flavonoid Natural Product Library Traditional Chinese Medicine Monomer Library Polyphenolic Natural Product Library Natural Product Library for HTS Anti-Tumor Natural Product Library Immunology/Inflammation Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-COVID-19 Compound Library

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Silymarin 65666-07-1 微生物学 SARS-CoV thistle angiogenesis Inhibitor hepatocellular resistance SARS coronavirus chemopreventive inhibit HCC Milk insulin proliferation carcinoma Silybin B inhibitor

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