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Sodium 4-phenylbutyrate

Catalog No. T1535 CAS 1716-12-7

Synonyms: Sodium Phenylbutyrate, Buphenyl, TriButyrate

Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.

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Sodium 4-phenylbutyrate Chemical Structure

Sodium 4-phenylbutyrate, CAS 1716-12-7

Pack Size	Availability	Price/USD
50 mg	In stock	$ 38.00
100 mg	In stock	$ 54.00
200 mg	In stock	$ 87.00
500 mg	In stock	$ 144.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 100%

Purity: 99.94%

Purity: 99.75%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.
In vitro	In G93A transgenic ALS mice, Phenylbutyrate improves clinical symptoms and increases survival. It induces the expression of NF-κB p50 in G93A mice, while reducing the expression of cytochrome c and caspases. Additionally, in transgenic mouse models of Huntington's disease (HD), Phenylbutyrate elevates brain protein acetylation levels and reduces histone methylation levels.
In vivo	In prostate cancer cells, Phenylbutyrate induces apoptosis by diminishing the expression levels of the cell apoptosis antagonist Bcl-X(L), the double-strand break repair protein DNA-dependent protein kinase, the prostate progression marker Caveolin-1, and the angiogenesis promoter Vascular Endothelial Growth Factor, thereby weakening their activity.

Synonyms	Sodium Phenylbutyrate, Buphenyl, TriButyrate
Molecular Weight	186.18
Formula	C10H11NaO2
CAS No.	1716-12-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 18.6 mg/mL (100 mM)

DMSO: 4.7 mg/mL (25 mM)

References and Literature

1. Gardian G, et al. Neuromolecular Med,2004, 5(3), 235-241. 2. Goh M, et al. Neoplasia,2001, 3(4), 331-338. 3. Ryu H, et al. J Neurochem,2005, 93(5), 1087-1098. 4. Gardian G, et al. J Biol Chem,2005, 280(1), 556-563.

Citations

1. Bai G, Wang H, Cui N. mTOR pathway mediates endoplasmic reticulum stress-induced CD4+ T cell apoptosis in septic mice. Apoptosis. 2022: 1-11

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Cancer Cell Differentiation Compound Library Anti-Breast Cancer Compound Library Anti-Cardiovascular Disease Compound Library Immunology/Inflammation Compound Library Anti-Aging Compound Library

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Keywords

Sodium 4-phenylbutyrate 1716-12-7 Apoptosis Autophagy Chromatin/Epigenetic DNA Damage/DNA Repair HDAC Histone deacetylases Benzenebutyric acid Sodium Phenylbutyrate 4-PBA 4-Phenylbutyric acid Tributyrate Buphenyl Inhibitor inhibit Sodium 4 phenylbutyrate Sodium 4phenylbutyrate TriButyrate inhibitor

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