Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Talipexole dihydrochloride (Domnin) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist, and 5-HT3 receptor antagonist in both rat cortical and intestinal membrane fractions with Ki values of 0.35 μM and 0.22 μM, respectively. It displays antiParkinsonian activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 32.00 | |
5 mg | In stock | $ 51.00 | |
10 mg | In stock | $ 82.00 | |
25 mg | In stock | $ 156.00 | |
50 mg | In stock | $ 278.00 | |
100 mg | In stock | $ 447.00 | |
200 mg | In stock | $ 646.00 | |
500 mg | In stock | $ 998.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 57.00 |
Description | Talipexole dihydrochloride (Domnin) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist, and 5-HT3 receptor antagonist in both rat cortical and intestinal membrane fractions with Ki values of 0.35 μM and 0.22 μM, respectively. It displays antiParkinsonian activity. |
Targets&IC50 | α2-adrenoceptor (rat):25 nM, 5-HT3 receptor:0.22 μM(Ki,rat intestinal membrane), 5-HT3 receptor:0.35 μM(Ki,rat cortical membrane) |
In vivo | Intracisternal injection of 10 μg/kg Talipexole dihydrochloride promotes vagal-mediated reflex bradycardia induced by injection of angiotensin in β-adrenoceptor-blocked dogs. Intravenous administration of Talipexole dihydrochloride at 30 mcg/kg initially caused an increase in blood pressure in cats. Then there is the long-term drop in blood pressure and heart rate[4]. |
Synonyms | Domnin, B-HT 920 dihydrochloride |
Molecular Weight | 282.23 |
Formula | C10H17Cl2N3S |
CAS No. | 36085-73-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (79.72 mM), Sonification and heating are recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Talipexole dihydrochloride 36085-73-1 GPCR/G Protein Neuroscience Adrenergic Receptor Dopamine Receptor 5-HT Receptor 5-hydroxytryptamine Receptor Talipexole Talipexole Dihydrochloride inhibit Domnin B-HT920 Dihydrochloride B-HT920 B-HT 920 Inhibitor B-HT-920 B-HT 920 Dihydrochloride B-HT 920 dihydrochloride Serotonin Receptor Beta Receptor B-HT-920 Dihydrochloride inhibitor