Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 41.00 | |
10 mg | In stock | $ 66.00 | |
25 mg | In stock | $ 124.00 | |
100 mg | In stock | $ 332.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower. |
Targets&IC50 | 5-HT3A:0.04 nM(Ki) |
In vitro | VUF10166 shows low activity to 5-HT3AB receptor with Ki of 22 nM. VUF10166 may be used to can distinguish between 5-HT3A and 5-HT3AB receptors. VUF10166 has no activity to α7 nACh receptor. VUF10166 also acts as a partial agonist at 5-HT3A receptors with EC50 of 5.2 μM, which shows that VUF10166 is unlikely to bind in the receptor pore. [1] |
Molecular Weight | 262.74 |
Formula | C13H15ClN4 |
CAS No. | 155584-74-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 26.3 mg/mL (100 mM)
DMSO: 26.3 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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VUF 10166 155584-74-0 GPCR/G Protein Neuroscience 5-HT Receptor 5-HT3A neurotransmission 5-HT3AB inhibit VUF-10166 5-HT3 receptor ligand 5-hydroxytryptamine Receptor Serotonin Receptor VUF10166 agonist Inhibitor inhibitor