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Vancomycin hydrochloride

Catalog No. T0832 CAS 1404-93-9

Synonyms: Vancomycin HCl

Vancomycin hydrochloride (Vancomycin HCl) is the hydrochloride salt of vancomycin, a branched tricyclic glycosylated peptide with bactericidal activity against most organisms and bacteriostatic effect on enterococci.

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Vancomycin hydrochloride Chemical Structure

Vancomycin hydrochloride, CAS 1404-93-9

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Purity: 925u/mg

Purity: 99.01%

Purity: 97.20%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Vancomycin hydrochloride (Vancomycin HCl) is the hydrochloride salt of vancomycin, a branched tricyclic glycosylated peptide with bactericidal activity against most organisms and bacteriostatic effect on enterococci.
In vitro	Vancomycin, a substantial glycopeptide antibiotic with a molecular weight of 1450 Da[1], stands out due to its unique structure and mode of action, distinguishing it from all currently available antibiotics. Its distinctive mechanism targets and inhibits the second stage of cell wall synthesis in susceptible bacteria. Active against an extensive array of Gram-positive species including Staphylococcus aureus, Staph. epidermidis, Str. agalactiae, Str. bovis, Str. mutans, viridans streptococci, and enterococci[2], vancomycin is a critical asset in treating various bacterial infections.
In vivo	Vancomycin is administered via intravenous infusion over a minimum of one hour to reduce the risk of infusion-related adverse effects. In individuals with normal creatinine clearance levels, the distribution phase (α) of vancomycin spans between 30 minutes to 1 hour, while the elimination half-life (β) ranges from 6 to 12 hours. Its distribution volume lies between 0.4–1 L/kg, and its protein-binding capacity varies between 10% and 50%. The efficacy of vancomycin is influenced by factors such as tissue distribution, inoculum size, and protein-binding impacts. Furthermore, vancomycin therapy in infected mice demonstrates significant improvements in clinical outcomes, diarrhea, histopathological scores, and survival rates during the course of treatment.

Synonyms	Vancomycin HCl
Molecular Weight	1485.71
Formula	C66H76Cl3N9O24
CAS No.	1404-93-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 33.33 mg/mL (22.43 mM), Sonication is recommended.

DMSO: 24 mg/mL (16.15 mM), Sonication and heating are recommended.

References and Literature

1. Rybak MJ, et al. The pharmacokinetic and pharmacodynamic properties of vancomycin. Clin Infect Dis. 2006 Jan 1;42 Suppl 1:S35-9. 2. Watanakunakorn C, et al. Mode of action and in-vitro activity of vancomycin. J Antimicrob Chemother. 1984 Dec;14 Suppl D:7-18. 3. Warren CA, et al. Vancomycin treatment's association with delayed intestinal tissue injury, clostridial overgrowth, and recurrence of Clostridium difficile infection in mice. Antimicrob Agents Chemother. 2013 Feb;57(2):689-96.

Citations

1. Zhang Z, Ye J, Liu X, et al.Huangqi Guizhi Wuwu decoction alleviates oxaliplatin-induced peripheral neuropathy via the gut-peripheral nerve axis.Chinese Medicine.2023, 18(1): 1-15. 2. Fang G, Wang S, Chen Q, et al.Time-restricted feeding affects the fecal microbiome metabolome and its diurnal oscillations in lung cancer mice.Neoplasia.2023, 45: 100943.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Microbial Natural Product Library Anti-Cancer Approved Drug Library Anti-Tumor Natural Product Library Anti-Bacterial Compound Library Anti-infective Natural Product Library Macrocyclic Compound Library NO PAINS Compound Library Cyclic Peptide Library

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Keywords

Vancomycin hydrochloride 1404-93-9 Autophagy Immunology/Inflammation Microbiology/Virology Cell wall Antibacterial Antibiotic inhibit Vancomycin Hydrochloride Bacterial Vancomycin Vancomycin HCl Inhibitor inhibitor

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