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Zamifenacin fumarate

Catalog No. T13385 CAS 127308-98-9

Synonyms: UK-76654 fumarate

Zamifenacin fumarate (UK-76654 fumarate) is a potent and gut-selective antagonist of muscarinic M3 receptor.

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Zamifenacin fumarate, CAS 127308-98-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
5 mg	In stock	$ 80.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 238.00
50 mg	In stock	$ 447.00
100 mg	In stock	$ 659.00
500 mg	In stock	$ 1,390.00
1 mL * 10 mM (in DMSO)	In stock	$ 94.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Zamifenacin fumarate (UK-76654 fumarate) is a potent and gut-selective antagonist of muscarinic M3 receptor.
In vivo	Zamifenacin exhibits terminal elimination half-lives (mouse 2.1, rat 6.0 and, dog 1.1 h) due to high plasma clearance (68, 35, and 39 mL/min/kg respectively combined with large volumes of distribution (12.5, 19.0, and 3.5 L/kg respectively) following intravenous administration (mouse 5.3, rat 5.0 and, dog 1.0 mg/kg)[2].

Synonyms	UK-76654 fumarate
Molecular Weight	531.6
Formula	C31H33NO7
CAS No.	127308-98-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 1 mg/mL (1.88 mM), Sonification and heating to 60℃ are recommended.

DMSO: 55 mg/ml (103.46 mM), Sonification is recommended

References and Literature

1. Houghton LA, et al. Zamifenacin (UK-76, 654) a potent gut M3 selective muscarinic antagonist, reduces colonic motor activity in patients with irritable bowel syndrome. Aliment Pharmacol Ther. 1997 Jun;11(3):561-8. 2. Beaumont KC, et al. Pharmacokinetics and metabolism of Zamifenacin in mouse, rat, dog and man. Xenobiotica. 1996 Apr;26(4):459-71.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Inhibitor Library Bioactive Compounds Library Max Neurotransmitter Receptor Compound Library ReFRAME Related Library Neuronal Signaling Compound Library Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Zamifenacin fumarate 127308-98-9 Neuroscience AChR gut UK 76654 bowel inhibit Zamifenacin Fumarate Inhibitor Muscarinic acetylcholine receptor UK-76654 UK76654 Fumarate muscarinic mAChR motility UK 76654 Fumarate syndrome UK-76654 fumarate irritable Zamifenacin UK76654 colonic UK-76654 Fumarate inhibitor

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