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Afacifenacin

Afacifenacin
Afacifenacin (SMP-986) fumarate is an M3 muscarinic receptor-selective antagonist used in the study of ischemic heart disease, urinary incontinence and cystitis and other disorders.
Catalog No. T29687Cas No. 877606-63-8
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Purity:99.57%
ee:97.48%
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Afacifenacin

Catalog No. T29687Cas No. 877606-63-8

Afacifenacin (SMP-986) fumarate is an M3 muscarinic receptor-selective antagonist used in the study of ischemic heart disease, urinary incontinence and cystitis and other disorders.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$350In Stock
5 mg$828In Stock
10 mg$1,130In Stock
25 mg$1,590In Stock
50 mg$1,980In Stock
100 mg$2,500In Stock
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Product Introduction

Bioactivity
Description
Afacifenacin (SMP-986) fumarate is an M3 muscarinic receptor-selective antagonist used in the study of ischemic heart disease, urinary incontinence and cystitis and other disorders.
In vivo
Afacifenacin (0.3, 1, 3 mg/kg; intragastric administration; male Sprague-Dawley rats) significantly increases bladder capacity and decreases voiding pressure (MP), without affecting residual urinary volume (RUV) in rats with cerebral infarction.[2]
AliasAfacifenacin fumarate, SMP-986, NS 986, NS-986, SMP 986, NS986, SMP986
Chemical Properties
Molecular Weight481.51
FormulaC27H26F3N3O2
Cas No.877606-63-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (103.84 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0768 mL10.3840 mL20.7680 mL103.8400 mL
5 mM0.4154 mL2.0768 mL4.1536 mL20.7680 mL
10 mM0.2077 mL1.0384 mL2.0768 mL10.3840 mL
20 mM0.1038 mL0.5192 mL1.0384 mL5.1920 mL
50 mM0.0415 mL0.2077 mL0.4154 mL2.0768 mL
100 mM0.0208 mL0.1038 mL0.2077 mL1.0384 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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