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Alethine (β-Alethine) is a small molecule compound with antitumour activity and is used to treat tumours and infections. The alethine-induced up-regulation of TNFα increases the cytotoxicity of T cells.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $143 | In Stock | |
5 mg | $360 | In Stock | |
10 mg | $530 | In Stock | |
25 mg | $859 | In Stock | |
50 mg | $1,180 | In Stock | |
100 mg | $1,590 | In Stock | |
500 mg | $3,190 | In Stock |
Description | Alethine (β-Alethine) is a small molecule compound with antitumour activity and is used to treat tumours and infections. The alethine-induced up-regulation of TNFα increases the cytotoxicity of T cells. |
In vitro | Alethine (Beta-alethine) (10 ng/ml) (a) adapts murine liver cells to culture (53 colonies/10(6) cells versus none in controls), (b) delays aging of human IMR-90 fetal lung fibroblasts (102 population doubling levels versus 47 in controls, producing 3 x 10(16) greater biomass), and (c) markedly stimulates antibody-producing plaque-forming cells from murine splenocytes (16,875/10(6) cells versus 55/10(6) cells in controls) or human peripheral blood leukocytes (1826/10(6) cells versus 0/10(6) cells in controls).[1] |
In vivo | Alethine (beta-alethine) (1 ng/kg to 100 micrograms/kg) successfully treat NS-1 myeloma in a syngeneic murine tumor model (NS-1 myeloma) when early interventions . Although there are indications in this model that beta-alethine is also effective when intervention is late, beta-alethine is ineffective in an allogeneic murine melanoma model (Cloudman S-91 melanoma).[1] |
Alias | β-Alethine |
Molecular Weight | 294.44 |
Formula | C10H22N4O2S2 |
Cas No. | 646-08-2 |
Smiles | N(CCSSCCNC(CCN)=O)C(CCN)=O |
Relative Density. | 1.31g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO: 1 mg/mL, Sonication is recommended. |
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