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AM580
AM580 (CD336) is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )
Catalog No. T5854Cas No. 102121-60-8
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Purity:99.89%
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AM580
Catalog No. T5854Cas No. 102121-60-8
AM580 (CD336) is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $33 | In Stock | |
| 5 mg | $52 | In Stock | |
| 10 mg | $79 | In Stock | |
| 25 mg | $167 | In Stock | |
| 50 mg | $333 | In Stock | |
| 100 mg | $493 | In Stock | |
| 500 mg | $1,120 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $58 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AM580 (CD336) is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM ) |
| In vitro | AM580 can inhibit the proliferation of various tumor cells,inhibiting survival signaling pathways and inducing apoptosis[1]. |
| In vivo | Modulation of the RARα/β to RARγ expression in mammary glands of normal mice, oncomice, and human mammary cell lines through the alteration of RAR-target gene expression affected cell proliferation, survival and tumor growth.?Treatment of MMTV-Myc mice with the RARα-selective agonist Am580 led to significant inhibition of mammary tumor growth (~90%, P<0.001), lung metastasis (P<0.01) and extended tumor latency in 63% of mice.?In these mice, RARα responsive genes such as Cyp26A1, E-cadherin, cellular retinol-binding protein 1 (CRBP1) and p27, were up-regulated[2]. |
| Cell Research | Ishikawa cells were transfected with control siRNA or siRNA specific against the RARα gene.Cells were treated with vehicle control or AM580 for 18 h.Cells were stained with trypan blue and counted[1]. |
| Animal Research | The effects of c-Myc on RAR isotype expression were evaluated in normal mouse mammary epithelium, mammary tumor cells obtained from the MMTV-Myc transgenic mouse model as well as human normal immortalized breast epithelial and breast cancer cell lines.?The in vivo effect of the RARα-selective agonist 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carboxamido]benzoic acid (Am580) was examined in the MMTV-Myc mouse model of mammary tumorigenesis[2]. |
| Alias | NSC608001, CD336, Ro 40-6055 |
| Molecular Weight | 351.44 |
| Formula | C22H25NO3 |
| Cas No. | 102121-60-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (113.82 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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