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Aplidine

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Purity:98.12%

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COA HPLC MS

Aplidine

Catalog No. T9715Cas No. 137219-37-5

Aplidine possesses antiviral activity against SARS-CoV-2(IC90 = 0.88 nM). Aplidine is a potent anti-cancer agent by targeting eukaryotic translation elongation factor 1 Alpha 2(EEF1A2, Kd = 80 nM).

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Pack Size	Price	Availability
1 mg	$297	In Stock
5 mg	$728	In Stock
10 mg	$987	In Stock
25 mg	$1,530	In Stock
50 mg	$1,980	In Stock
1 mL x 10 mM (in DMSO)	$1,330	In Stock

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Product Introduction

Bioactivity

Description	Aplidine possesses antiviral activity against SARS-CoV-2(IC90 = 0.88 nM). Aplidine is a potent anti-cancer agent by targeting eukaryotic translation elongation factor 1 Alpha 2(EEF1A2, Kd = 80 nM).
In vitro	In hACE2-293T cells, Aplidine exhibits anti–SARS-CoV-2 activity with an IC90 of 0.88 nM. In an established model of human pneumocyte-like cells, Aplidine inhibits SARS-CoV-2 replication with an IC90 of 3.14 nM and a selectivity index of 40.4[1]. Aplidine (20 nM; 1 h) induces a dose-dependent decrease in VEGF secretion in MOLT-4 cells. Aplidine (20 nM; 1 h) does not result in significant inhibition of VEGF-R1 mRNA in normal endothelial cells, which do express VEGFR-1 but do not secrete VEGF[1].
In vivo	In BALB/c mice expressing human ACE2, Aplidine significantly reduced SARS-CoV-2 infection. 0.3 mg/kg Aplidine group results in a reduction of nearly 2 log units in SARS-CoV-2 viral titers in the lungs, and the 1 mg/kg group leads to a reduction of 1.5 log units[2].

Chemical Properties

Molecular Weight	1110.34
Formula	C57H87N7O15
Cas No.	137219-37-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (90.06 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9006 mL	4.5031 mL	9.0063 mL	45.0313 mL
5 mM	0.1801 mL	0.9006 mL	1.8013 mL	9.0063 mL
10 mM	0.0901 mL	0.4503 mL	0.9006 mL	4.5031 mL
20 mM	0.0450 mL	0.2252 mL	0.4503 mL	2.2516 mL
50 mM	0.0180 mL	0.0901 mL	0.1801 mL	0.9006 mL

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