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APS6-45

🥰Excellent
Catalog No. T8843Cas No. 2188236-41-9

APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.

APS6-45

APS6-45

🥰Excellent
Purity: 99.39%
Catalog No. T8843Cas No. 2188236-41-9
APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.
Pack SizePriceAvailabilityQuantity
2 mg31 €In Stock
5 mg76 €In Stock
10 mg122 €In Stock
25 mg249 €In Stock
50 mg401 €In Stock
100 mg615 €In Stock
200 mg829 €In Stock
1 mL x 10 mM (in DMSO)93 €In Stock
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Purity:99.39%
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Product Introduction

Bioactivity
Description
APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.
In vitro
APS6-45 (1 μM; 1 h) strongly inhibits RAS pathway activity signaling in human MTC cell lines TT and MZ-CRC-1[1].
In vivo
APS6-45 did not affect body weight of dosed(10 mg/kg) mice after 30 d.APS6-45 (0.1-160 mg/kg; a single p.o.) does not cause detectable toxic effects in mice[1].
Chemical Properties
Molecular Weight548.39
FormulaC23H16F8N4O3
Cas No.2188236-41-9
SmilesCNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(ccc3F)C(F)(C(F)(F)F)C(F)(F)F)cc2)ccn1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 240 mg/mL (437.67 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8235 mL9.1176 mL18.2352 mL91.1760 mL
5 mM0.3647 mL1.8235 mL3.6470 mL18.2352 mL
10 mM0.1824 mL0.9118 mL1.8235 mL9.1176 mL
20 mM0.0912 mL0.4559 mL0.9118 mL4.5588 mL
50 mM0.0365 mL0.1824 mL0.3647 mL1.8235 mL
100 mM0.0182 mL0.0912 mL0.1824 mL0.9118 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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