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ASK1-IN-2

ASK1-IN-2 is a potent, orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. It has potential therapeutic applications for ulcerative colitis[1].

Catalog No. T9377Cas No. 2541792-70-3

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Purity:98.79%

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COA HNMR HPLC LCMS

ASK1-IN-2

Catalog No. T9377Cas No. 2541792-70-3

ASK1-IN-2 is a potent, orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. It has potential therapeutic applications for ulcerative colitis[1].

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$68	In Stock
5 mg	$163	In Stock
10 mg	$263	In Stock
25 mg	$476	In Stock
50 mg	$715	In Stock
100 mg	$1,070	In Stock
1 mL x 10 mM (in DMSO)	$179	In Stock

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Product Introduction

Bioactivity

Description	ASK1-IN-2 is a potent, orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. It has potential therapeutic applications for ulcerative colitis[1].
Targets&IC50	ASK1:32.8 nM (IC50)
In vitro	ASK1-IN-2 displays potent anti-ASK1 kinase activity and strong inhibitory effect on ASK1 in AP1-HEK293 cells with inhibition rate of 95.59%[1].
In vivo	ASK1-IN-2 (1 mg/kg; i.v.) shows low clearance (CL=1.38 L/h/kg) and moderate half-life (T1/2=1.45 h) in rats[1]. ASK1-IN-2 (10 mg/kg; p.o.) shows high oral exposure (AUClast=4517 h?ng/mL), 62.2% oral bioavailability and acceptable terminal half-life (T1/2=2.31 h) in rats[1]. ASK1-IN-2 (25 mg/kg; p.o. daily for 7 d) improves dextran sulphate sodium (DSS)-induced ulcerative colitis (UC) in mice[1]. ASK1-IN-2 (25 mg/kg; p.o. daily for 7 d) blocks ASK1-p38/JNK signaling pathways and reduces inflammatory cytokine levels in DSS-induced mouse colon tissues[1].

Chemical Properties

Molecular Weight	364.38
Formula	C₁₉H₁₇FN₆O
Cas No.	2541792-70-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 249 mg/mL (683.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7444 mL	13.7219 mL	27.4439 mL	137.2194 mL
5 mM	0.5489 mL	2.7444 mL	5.4888 mL	27.4439 mL
10 mM	0.2744 mL	1.3722 mL	2.7444 mL	13.7219 mL
20 mM	0.1372 mL	0.6861 mL	1.3722 mL	6.8610 mL
50 mM	0.0549 mL	0.2744 mL	0.5489 mL	2.7444 mL
100 mM	0.0274 mL	0.1372 mL	0.2744 mL	1.3722 mL

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