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Pack Size | Price | Availability | Quantity |
---|---|---|---|
200 mg | $31 | In Stock | |
500 mg | $46 | In Stock | |
1 g | $53 | In Stock | |
5 g | $87 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Aspirin is a histone deacetylase inhibitors to up-regulate cell cycle arrest protein p21, which can suppresses ovarian Y cells harboring COX-1. Aspirin also inhibits the expression of COX-2 in HUVEC and neonatal rat ventricular cardiomyocytes, and then reduce PG production and the down-regulation of ERK and NF-KB, respectively. |
Cell Research | Chondrocytes are isolated from articular cartilage of donors with no articular disease. Unstimulated and interleukin 1 (IL-1) stimulated chondrocytes are used as models to study the effects of drugs on COX-1 and COX-2. Cells are incubated with vehicle or drugs (Asprin); supernatants are removed and the level of prostaglandin E2 (PGE2) in each sample is determined by enzyme immunoassay. IC50s are calculated from the reduction in PGE2 content by different concentrations of the test substance by linear regression analysis[5]. |
Alias | Acetylsalicylate, Acetylsalicylic Acid, ASA |
Molecular Weight | 180.16 |
Formula | C9H8O4 |
Cas No. | 50-78-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 1.80 mg/mL (10 mM) ![]() DMSO: 50 mg/mL (277.53 mM) ![]() | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
DMSO
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