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Tuvusertib

🥰Excellent
Catalog No. T10406Cas No. 1613200-51-3
Alias M1774, ATR inhibitor 1

Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activity.Tuvusertib selectively inhibits ATR activity and blocks downstream phosphorylation of serine/threonine protein kinase checkpoint kinase 1 (CHK1), thereby inhibits DNA damage checkpoint activation, disrupting DNA damage repair and inducing apoptosis in tumor cells.

Tuvusertib

Tuvusertib

🥰Excellent
Purity: 99.66%
Catalog No. T10406Alias M1774, ATR inhibitor 1Cas No. 1613200-51-3
Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activity.Tuvusertib selectively inhibits ATR activity and blocks downstream phosphorylation of serine/threonine protein kinase checkpoint kinase 1 (CHK1), thereby inhibits DNA damage checkpoint activation, disrupting DNA damage repair and inducing apoptosis in tumor cells.
Pack SizePriceAvailabilityQuantity
1 mg$68In Stock
5 mg$165In Stock
10 mg$257In Stock
25 mg$496In Stock
50 mg$692In Stock
100 mg$979In Stock
1 mL x 10 mM (in DMSO)$187In Stock
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Purity:99.66%
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Product Introduction

Bioactivity
Description
Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activity.Tuvusertib selectively inhibits ATR activity and blocks downstream phosphorylation of serine/threonine protein kinase checkpoint kinase 1 (CHK1), thereby inhibits DNA damage checkpoint activation, disrupting DNA damage repair and inducing apoptosis in tumor cells.
AliasM1774, ATR inhibitor 1
Chemical Properties
Molecular Weight370.32
FormulaC16H12F2N8O
Cas No.1613200-51-3
SmilesCn1cncc1-c1c(F)cncc1NC(=O)c1c(N)nn2cc(F)cnc12
Relative Density.1.68 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 6.25 mg/mL (16.88 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7004 mL13.5018 mL27.0037 mL135.0184 mL
5 mM0.5401 mL2.7004 mL5.4007 mL27.0037 mL
10 mM0.2700 mL1.3502 mL2.7004 mL13.5018 mL

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