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BAY 87-2243

BAY 87-2243
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Purity:99.77%
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BAY 87-2243

Catalog No. T2488Cas No. 1227158-85-1
BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
2 mg$38In Stock
5 mg$60In Stock
10 mg$109In Stock
25 mg$235In Stock
50 mg$453In Stock
100 mg$689In Stock
1 mL x 10 mM (in DMSO)$70In Stock
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Product Introduction

Bioactivity
Description
BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
In vitro
BAY87-2243 (administered orally at 4 mg/kg) reduced tumor weight, HIF-1α protein, and HIF-1 target gene expression levels in an H460 xenograft mouse model.
In vivo
In hypoxic lung cancer H460 cells, BAY 87-2243 inhibits the expression of HIF target genes and suppresses the accumulation of HIF-1α protein. It impairs cell proliferation by interfering with mitochondrial function under glucose consumption. Additionally, BAY 87-2243 inhibits the reporter gene activity of HIF-1 and the expression of CA9 protein, with IC50 values of 0.7 nM and 2 nM, respectively.
Cell Research
To evaluate the cytotoxicity of BAY 87-2243, 2.000 cells of the respective cell lines are seeded in 96-well plates and cultured in the appropriate growth medium containing 10% FCS. BAY 87-2243 at various concentrations is added at 24 h after seeding for additional 48 h and cell viability is determined using Cell Titer Glow Assay.(Only for Reference)
Chemical Properties
Molecular Weight525.53
FormulaC26H26F3N7O2
Cas No.1227158-85-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 52.55 mg/mL (100 mM), Sonication and heating are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9028 mL9.5142 mL19.0284 mL95.1420 mL
5 mM0.3806 mL1.9028 mL3.8057 mL19.0284 mL
10 mM0.1903 mL0.9514 mL1.9028 mL9.5142 mL
20 mM0.0951 mL0.4757 mL0.9514 mL4.7571 mL
50 mM0.0381 mL0.1903 mL0.3806 mL1.9028 mL
100 mM0.0190 mL0.0951 mL0.1903 mL0.9514 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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