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BAY 87-2243

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Catalog No. T2488Cas No. 1227158-85-1

BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).

BAY 87-2243

BAY 87-2243

🥰Excellent
Purity: 99.77%
Catalog No. T2488Cas No. 1227158-85-1
BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
Pack SizePriceAvailabilityQuantity
2 mg$38 In Stock
5 mg$60 In Stock
10 mg$109 In Stock
25 mg$235 In Stock
50 mg$453 In Stock
100 mg$689 In Stock
1 mL x 10 mM (in DMSO)$70 In Stock
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Purity:99.77%
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Product Introduction

Bioactivity
Description
BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
In vitro
BAY87-2243 (administered orally at 4 mg/kg) reduced tumor weight, HIF-1α protein, and HIF-1 target gene expression levels in an H460 xenograft mouse model.
In vivo
In hypoxic lung cancer H460 cells, BAY 87-2243 inhibits the expression of HIF target genes and suppresses the accumulation of HIF-1α protein. It impairs cell proliferation by interfering with mitochondrial function under glucose consumption. Additionally, BAY 87-2243 inhibits the reporter gene activity of HIF-1 and the expression of CA9 protein, with IC50 values of 0.7 nM and 2 nM, respectively.
Cell Research
To evaluate the cytotoxicity of BAY 87-2243, 2.000 cells of the respective cell lines are seeded in 96-well plates and cultured in the appropriate growth medium containing 10% FCS. BAY 87-2243 at various concentrations is added at 24 h after seeding for additional 48 h and cell viability is determined using Cell Titer Glow Assay.(Only for Reference)
Chemical Properties
Molecular Weight525.53
FormulaC26H26F3N7O2
Cas No.1227158-85-1
SmilesCc1cc(nn1Cc1ccnc(c1)N1CCN(CC1)C1CC1)-c1nc(no1)-c1ccc(OC(F)(F)F)cc1
Relative Density.1.47 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 52.55 mg/mL (100 mM), Sonication and heating are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9028 mL9.5142 mL19.0284 mL95.1420 mL
5 mM0.3806 mL1.9028 mL3.8057 mL19.0284 mL
10 mM0.1903 mL0.9514 mL1.9028 mL9.5142 mL
20 mM0.0951 mL0.4757 mL0.9514 mL4.7571 mL
50 mM0.0381 mL0.1903 mL0.3806 mL1.9028 mL
100 mM0.0190 mL0.0951 mL0.1903 mL0.9514 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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