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BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $38 | In Stock | |
5 mg | $60 | In Stock | |
10 mg | $109 | In Stock | |
25 mg | $235 | In Stock | |
50 mg | $453 | In Stock | |
100 mg | $689 | In Stock | |
1 mL x 10 mM (in DMSO) | $70 | In Stock |
Description | BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1). |
In vitro | BAY87-2243 (administered orally at 4 mg/kg) reduced tumor weight, HIF-1α protein, and HIF-1 target gene expression levels in an H460 xenograft mouse model. |
In vivo | In hypoxic lung cancer H460 cells, BAY 87-2243 inhibits the expression of HIF target genes and suppresses the accumulation of HIF-1α protein. It impairs cell proliferation by interfering with mitochondrial function under glucose consumption. Additionally, BAY 87-2243 inhibits the reporter gene activity of HIF-1 and the expression of CA9 protein, with IC50 values of 0.7 nM and 2 nM, respectively. |
Cell Research | To evaluate the cytotoxicity of BAY 87-2243, 2.000 cells of the respective cell lines are seeded in 96-well plates and cultured in the appropriate growth medium containing 10% FCS. BAY 87-2243 at various concentrations is added at 24 h after seeding for additional 48 h and cell viability is determined using Cell Titer Glow Assay.(Only for Reference) |
Molecular Weight | 525.53 |
Formula | C26H26F3N7O2 |
Cas No. | 1227158-85-1 |
Smiles | Cc1cc(nn1Cc1ccnc(c1)N1CCN(CC1)C1CC1)-c1nc(no1)-c1ccc(OC(F)(F)F)cc1 |
Relative Density. | 1.47 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 52.55 mg/mL (100 mM), Sonication and heating are recommended. ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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