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Bemesetron
🥰Excellent
Catalog No. T14526Cas No. 40796-97-2
Alias TROPANYL 3,5-DICHLOROBENZOATE, MDL 72222, 3-TROPANYL-3,5-DICHLOROBENZOATE
Bemesetron (MDL 72222) is a selective 5-HT3 antagonist (IC50 = 0.33 nM) that exhibits neuroprotective effects.
Bemesetron
🥰Excellent
Purity: 97.37%
Catalog No. T14526Alias TROPANYL 3,5-DICHLOROBENZOATE, MDL 72222, 3-TROPANYL-3,5-DICHLOROBENZOATECas No. 40796-97-2
Bemesetron (MDL 72222) is a selective 5-HT3 antagonist (IC50 = 0.33 nM) that exhibits neuroprotective effects.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $50 | In Stock | |
| 25 mg | $64 | In Stock | |
| 50 mg | $86 | In Stock |
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CitedSelect Batch
Purity:97.37%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Bemesetron (MDL 72222) is a selective 5-HT3 antagonist (IC50 = 0.33 nM) that exhibits neuroprotective effects. |
| Targets&IC50 | 5-HT3 receptor:0.33 nM |
| In vitro | In primary cortical neuronal cells, Bemesetron (1 μM) significantly blocks the H2O2-induced increase of caspase-3 immunoreactivity. Bemesetron (0.01, 0.1 and 1 μM) and Y25130 (0.05, 0.5 and 5 μM) concentration-dependently reduce the H2O2-induced decrease showing inhibition of 74.9 and 79.0% with 1 μM and 5 μM, respectively[2]. |
| In vivo | In male adult albino mice, Bemesetron (1 mg/kg; i.p.) causes a significant reduction of catalepsy, while Bemesetron (10 mg/kg; i.p.) significantly potentiates the phenomenon. The maximum inhibition of catalepsy (about 75%) occurs at 120 min, and the maximum potentiation (about 4.5-times the control value) occurs at 60 min after Haloperidol[3]. |
| Alias | TROPANYL 3,5-DICHLOROBENZOATE, MDL 72222, 3-TROPANYL-3,5-DICHLOROBENZOATE |
| Molecular Weight | 314.21 |
| Formula | C15H17Cl2NO2 |
| Cas No. | 40796-97-2 |
| Smiles | CN1[C@@H]2CC[C@@H]1CC(C2)OC(=O)c1cc(Cl)cc(Cl)c1 |
| Relative Density. | 1.34 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 2 mg/mL (6.37 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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