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Bemnifosbuvir

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Purity:99.69%

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COA HPLC HNMR

Bemnifosbuvir

Catalog No. T9341Cas No. 1998705-64-8

Bemnifosbuvir (AT-511) is a novel phosphoramidate prodrug of 2'-fluoro-2'-C-methylguanosine-5'-monophosphate that has potent in vitro activity against HCV.

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Pack Size	Price	Availability
1 mg	$98	In Stock
5 mg	$249	In Stock
10 mg	$416	In Stock
25 mg	$692	In Stock
50 mg	$985	In Stock
100 mg	$1,330	In Stock
1 mL x 10 mM (in DMSO)	$525	In Stock

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Product Introduction

Bioactivity

Description	Bemnifosbuvir (AT-511) is a novel phosphoramidate prodrug of 2'-fluoro-2'-C-methylguanosine-5'-monophosphate that has potent in vitro activity against HCV.
In vitro	AT-511 is a novel phosphoramidate prodrug of 2'-fluoro-2'-C-methylguanosine-5'-monophosphate that has potent in vitro activity against HCV[1].In the absence of cells, AT-511 was stable when incubated in culture medium at 37°C for up to 24 h. AT-9010 was the predominant intracellular metabolite measured in all hepatocyte species and Huh-7 cell incubations with 10 μM AT-511 and, except in mouse hepatocytes,far exceeded intracellular AT-511 concentrations,demonstrating that the active TP was efficiently formed from its phosphoramidate protide in liver cells. In hepatocyte incubations, the relative levels of AT-9010 formed, and its accumulation over 24 h expressed as area under the curve or AUC0-24h; from most to least abundant, were rat>human >mouse >dog/monkey.
In vivo	Treatment with moxifloxacin every 8?hr was accompanied by longer survival than in any other group.Tissue cultures 30?hr after bacterial challenge showed considerably less bacterial growth in the spleens and lungs of moxifloxacin-treated animals than in the other groups, but not in their livers[2].
Alias	AT-511

Chemical Properties

Molecular Weight	581.53
Formula	C24H33FN7O7P
Cas No.	1998705-64-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (163.36 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7196 mL	8.5980 mL	17.1960 mL	85.9801 mL
5 mM	0.3439 mL	1.7196 mL	3.4392 mL	17.1960 mL
10 mM	0.1720 mL	0.8598 mL	1.7196 mL	8.5980 mL
20 mM	0.0860 mL	0.4299 mL	0.8598 mL	4.2990 mL
50 mM	0.0344 mL	0.1720 mL	0.3439 mL	1.7196 mL
100 mM	0.0172 mL	0.0860 mL	0.1720 mL	0.8598 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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