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Cabotegravir

🥰Excellent
Catalog No. T6098Cas No. 1051375-10-0
Alias S/GSK1265744, GSK744, GSK-1265744

Cabotegravir (S/GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM).

Cabotegravir

Cabotegravir

🥰Excellent
Purity: 99.92%
Catalog No. T6098Alias S/GSK1265744, GSK744, GSK-1265744Cas No. 1051375-10-0
Cabotegravir (S/GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM).
Pack SizePriceAvailabilityQuantity
10 mg$46In Stock
25 mg$89In Stock
50 mg$158In Stock
100 mg$198In Stock
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Purity:99.92%
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Product Introduction

Bioactivity
Description
Cabotegravir (S/GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM).
Targets&IC50
HIV-1:3.0 nM
In vivo
GSK1265744 (50 mg/kg) effectively prevents high-dose SHIV infection in rhesus macaques.
Kinase Assay
In vitro strand transfer assay: The inhibitory concentrations of GSK1265744 is measured in a strand transfer assay using recombinant HIV IN. A complex of integrase and biotinylated donor DNA–streptavidin-coated SPA beads is formed by incubating 2 μM purified recombinant integrase with 0.66 μM biotinylated donor DNA–4 mg/mL streptavidin-coated SPA beads in 25 mM sodium MOPS pH 7.2, 23 mM NaCl, and 10 mM MgCl2 for 5 minutes at 37°C. These beads are spun down and preincubated with diluted INSTIs for 60 minutes at 37°C. Next, [3H]-labeled target DNA substrate is added to give a final concentration of 7 nM substrate, and the strand transfer reaction is incubated at 37°C for 25 to 45 minutes, which allowed for a linear increase in strand transfer of donor DNA to radiolabeled target DNA. The signal is read using a Wallac MicroBeta scintillation plate reader.
AliasS/GSK1265744, GSK744, GSK-1265744
Chemical Properties
Molecular Weight405.35
FormulaC19H17F2N3O5
Cas No.1051375-10-0
SmilesO=C1C=2N(C[C@@]3(N1[C@@H](C)CO3)[H])C=C(C(NCC4=C(F)C=C(F)C=C4)=O)C(=O)C2O
Relative Density.1.57 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: <1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)

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