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Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 mg | $38 | In Stock | |
100 mg | $51 | In Stock | |
200 mg | $76 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Clemastine fumarate (Meclastine (fumarate)) is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties. |
Targets&IC50 | H1 receptor:3 nM |
In vitro | In rats, Clemastine Fumarate (5-20 mg/kg) significantly inhibits yeast polysaccharide-induced paw edema and croton oil-induced ear swelling in a dose-dependent manner. |
In vivo | In HL-60 cells, Clemastine Fumarate (IC50=3 nM) effectively inhibits histamine-induced increases in Ca2+ levels. In the human leukemia cell line K562 and the human B-lymphoblast cell line SB, concentrations of Clemastine Fumarate ≥25 μM significantly suppress both natural killer (NK) cell and antibody-dependent cell-mediated cytotoxicity (ADCC) activities. Additionally, Clemastine Fumarate potently inhibits the HERG K+ channel in HEK 293 cells stably expressing the channel (IC50=12 nM). |
Alias | HS-592 (fumarate), Meclastine fumarate, Meclastine (fumarate) |
Molecular Weight | 459.97 |
Formula | C25H30ClNO5 |
Cas No. | 14976-57-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 9 mg/mL (19.57 mM), Sonication is recommended. ![]() | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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