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CM-272

Catalog No. T7194Cas No. 1846570-31-7

CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.

CM-272

CM-272

Purity: 98.21%
Catalog No. T7194Cas No. 1846570-31-7
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
Pack SizePriceAvailabilityQuantity
1 mg$67In Stock
5 mg$163In Stock
10 mg$289In Stock
25 mg$538In Stock
50 mg$777In Stock
100 mg$1,090In Stock
1 mL x 10 mM (in DMSO)$173In Stock
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Purity:98.21%
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Product Introduction

Bioactivity
Description
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
Targets&IC50
DNMT1:382 nM, G9a:8 nM, DNMT3B:1200 nM (IC50), GLP:2 nM, DNMT3A:85 nM
In vitro
CM-272, inhibits cell proliferation and promotes apoptosis, inducing interferon-stimulated genes and immunogenic cell death. CM-272 significantly prolongs survival of AML, ALL and DLBCL xenogeneic models.
In vivo
CM-272 (2.5 mg/kg; intravenous injection; daily; for 28 days; female Rag2?/?γc?/? mice) treatment significantly prolongs survival of CEMO-1 cells xenogeneic models.Induced a statistically significant increase in overall survival (OS) in mice.
Cell Research
Cell Line:CEMO-1, MV4-11 and OCI-Ly10 cell lines. Concentration:125 nM, 250 nM, 500 nM (CEMO-1 cells); 135 nM, 270 nM, 540 nM (MV4-11 cells); 100 nM, 400 nM, 1000 nM (OCI-Ly10 cells). Incubation Time:12 hours, 24 hours, 48 hours and 72?hours
Animal Research
CM-272 (2.5 mg/kg; intravenous injection; daily; for 28 days; female Rag2?/?γc?/? mice) treatment significantly prolongs survival of CEMO-1 cells xenogeneic models. Animal Model:Female BALB/Ca-Rag2?/?γc?/? mice (6–8-week-old) with CEMO-1 cells. Dosage:2.5 mg/kg. Administration:Intravenous injection; daily; for 28 days
Chemical Properties
Molecular Weight478.63
FormulaC28H38N4O3
Cas No.1846570-31-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 96 mg/mL (200.57 mM)
Ethanol: 96 mg/mL (200.57 mM)
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM2.0893 mL10.4465 mL20.8930 mL104.4648 mL
5 mM0.4179 mL2.0893 mL4.1786 mL20.8930 mL
10 mM0.2089 mL1.0446 mL2.0893 mL10.4465 mL
20 mM0.1045 mL0.5223 mL1.0446 mL5.2232 mL
50 mM0.0418 mL0.2089 mL0.4179 mL2.0893 mL
100 mM0.0209 mL0.1045 mL0.2089 mL1.0446 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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