Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

CM-272

🥰Excellent
Catalog No. T7194Cas No. 1846570-31-7

CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.

CM-272

CM-272

🥰Excellent
Purity: 98.21%
Catalog No. T7194Cas No. 1846570-31-7
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
Pack SizePriceAvailabilityQuantity
1 mg$67In Stock
5 mg$163In Stock
10 mg$289In Stock
25 mg$538In Stock
50 mg$777In Stock
100 mg$1,090In Stock
1 mL x 10 mM (in DMSO)$173In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "CM-272"

Select Batch
Purity:98.21%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
Targets&IC50
DNMT1:382 nM, G9a:8 nM, DNMT3B:1200 nM (IC50), GLP:2 nM, DNMT3A:85 nM
In vitro
CM-272, inhibits cell proliferation and promotes apoptosis, inducing interferon-stimulated genes and immunogenic cell death. CM-272 significantly prolongs survival of AML, ALL and DLBCL xenogeneic models.
In vivo
CM-272 (2.5 mg/kg; intravenous injection; daily; for 28 days; female Rag2?/?γc?/? mice) treatment significantly prolongs survival of CEMO-1 cells xenogeneic models.Induced a statistically significant increase in overall survival (OS) in mice.
Cell Research
Cell Line:CEMO-1, MV4-11 and OCI-Ly10 cell lines. Concentration:125 nM, 250 nM, 500 nM (CEMO-1 cells); 135 nM, 270 nM, 540 nM (MV4-11 cells); 100 nM, 400 nM, 1000 nM (OCI-Ly10 cells). Incubation Time:12 hours, 24 hours, 48 hours and 72?hours
Animal Research
CM-272 (2.5 mg/kg; intravenous injection; daily; for 28 days; female Rag2?/?γc?/? mice) treatment significantly prolongs survival of CEMO-1 cells xenogeneic models. Animal Model:Female BALB/Ca-Rag2?/?γc?/? mice (6–8-week-old) with CEMO-1 cells. Dosage:2.5 mg/kg. Administration:Intravenous injection; daily; for 28 days
Chemical Properties
Molecular Weight478.63
FormulaC28H38N4O3
Cas No.1846570-31-7
SmilesCOc1cc2c(NC3CCN(C)CC3)cc(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Relative Density.1.164 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 96 mg/mL (200.57 mM)
Ethanol: 96 mg/mL (200.57 mM)
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM2.0893 mL10.4465 mL20.8930 mL104.4648 mL
5 mM0.4179 mL2.0893 mL4.1786 mL20.8930 mL
10 mM0.2089 mL1.0446 mL2.0893 mL10.4465 mL
20 mM0.1045 mL0.5223 mL1.0446 mL5.2232 mL
50 mM0.0418 mL0.2089 mL0.4179 mL2.0893 mL
100 mM0.0209 mL0.1045 mL0.2089 mL1.0446 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy CM-272 | purchase CM-272 | CM-272 cost | order CM-272 | CM-272 chemical structure | CM-272 in vivo | CM-272 in vitro | CM-272 formula | CM-272 molecular weight