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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $131 | In Stock | |
50 mg | $744 | In Stock | |
100 mg | $1,120 | In Stock |
Description | Cyamemazine is an antipsychotic compound with sedative and anxiolytic activity. Cyamemazine is a 5-HT3, 5-HT2A, and 5-HT2C receptor antagonist with Ki values of 12 nM, 1.5 nM, and 75 nM, respectively. |
Targets&IC50 | 5-HT2A Receptor:1.5 nM (Ki), 5-HT3 Receptor:75 nM (Ki), 5-HT2C Receptor:12 nM (Ki) |
In vitro | METHODS: The antagonistic effects of Cyamemazine on various receptors, such as D2, 5-HT2A, 5-HT2C, and 5-HT3 receptors, were determined through binding experiments. RESULTS: Cyamemazine showed strong antagonistic effects on D2 and 5-HT2A receptors, and relatively weaker antagonistic effects on 5-HT2C and 5-HT3 receptors. This receptor activity is associated with its anxiolytic effects [1]. |
In vivo | METHODS: The Elevated Plus Maze (EPM) test was conducted in mice to evaluate the anxiolytic-like behavior of Cyamemazine under acute and chronic dosing conditions. RESULTS: In the acute dosing condition, Cyamemazine exhibited anxiolytic-like activity in the light/dark exploration test. In the chronic dosing condition, it increased the time spent in the open arms of the Elevated Plus Maze, demonstrating its anxiolytic effects [1]. |
Molecular Weight | 323.46 |
Formula | C19H21N3S |
Cas No. | 3546-03-0 |
Storage | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (247.32 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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