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CyPPA
🥰Excellent
Catalog No. T20968Cas No. 73029-73-9
CyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization.
CyPPA
🥰Excellent
Purity: 99.72%
Catalog No. T20968Cas No. 73029-73-9
CyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $37 | In Stock | |
| 5 mg | $59 | In Stock | |
| 10 mg | $84 | In Stock | |
| 25 mg | $178 | In Stock | |
| 50 mg | $296 | In Stock | |
| 100 mg | $490 | In Stock | |
| 500 mg | $1,080 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $64 | In Stock |
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Purity:99.72%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization. |
| Targets&IC50 | SK2:5.6 μM (EC50), SK3:14 μM (EC50) |
| In vitro | CyPPA, a positive modulator of SK2 and SK3, reduces the activity of dopaminergic neurons and inhibits dopamine release with EC50 values of 14 μM and 5.6 μM, repectively. CyPPA counteracts hyperdopaminergic behaviors induced by methylphenidate. |
| In vivo | In vivo studies revealed that systemic administration of CyPPA attenuated methylphenidate-induced hyperactivity and stereotypic behaviors in mice. CyPPA induces a concentration-dependent increase in the apparent Ca2+ sensitivity of channel activation, changing the EC50 (Ca2+) from 429 nM to 59 nM |
| Molecular Weight | 285.39 |
| Formula | C16H23N5 |
| Cas No. | 73029-73-9 |
| Smiles | Cc1cc(C)n(n1)-c1nc(C)cc(NC2CCCCC2)n1 |
| Relative Density. | 1.23 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 99 mg/mL (346.89 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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