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Eflornithine
🥰Excellent
Catalog No. T40811Cas No. 70052-12-9
Alias α-difluoromethylornithine, RMI71782, MDL71782, DFMO
Eflornithine (DFMO) is a selective and orally available ornithine decarboxylase inhibitor that delays hair overgrowth.Eflornithine is used in the study of African trypanosomiasis, malignant glioma, and sleeping sickness.
Eflornithine
🥰Excellent
Purity: 99.44%
Catalog No. T40811Alias α-difluoromethylornithine, RMI71782, MDL71782, DFMOCas No. 70052-12-9
Eflornithine (DFMO) is a selective and orally available ornithine decarboxylase inhibitor that delays hair overgrowth.Eflornithine is used in the study of African trypanosomiasis, malignant glioma, and sleeping sickness.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $29 | In Stock |
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Purity:99.44%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Eflornithine (DFMO) is a selective and orally available ornithine decarboxylase inhibitor that delays hair overgrowth.Eflornithine is used in the study of African trypanosomiasis, malignant glioma, and sleeping sickness. |
| In vivo | Eflornithine is the only newly registered molecule for the treatment of human African trypanosomiasis in the past 50 years, mainly serving as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[1]. In subjects with excessive facial hair, eflornithine 15% cream reduces hair growth more effectively than placebo, with 58% of eflornithine users showing improvement after 24 weeks compared to 34% for placebo[2]. The hair growth inhibitory effect is significantly enhanced when eflornithine cream is applied to mouse skin pretreated with microneedles[3]. In coarctation hypertensive rats, eflornithine treatment normalizes contractile responses to KCI and norepinephrine and acetylcholine-induced relaxations after 14 days[4]. |
| Alias | α-difluoromethylornithine, RMI71782, MDL71782, DFMO |
| Molecular Weight | 182.17 |
| Formula | C6H12F2N2O2 |
| Cas No. | 70052-12-9 |
| Smiles | O=C(O)C(N)(CCCN)C(F)F |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 50 mg/mL (274.47 mM), Sonication and heating are recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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