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Epothilone A
🥰Excellent
Catalog No. T6490Cas No. 152044-53-6
Alias epothile, Epo A
Epothilone A (Epo A) is a microtubule-stabilizing agent with EC0.01 of 2 μM.
Epothilone A
🥰Excellent
Purity: 99.89%
Catalog No. T6490Alias epothile, Epo ACas No. 152044-53-6
Epothilone A (Epo A) is a microtubule-stabilizing agent with EC0.01 of 2 μM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $43 | In Stock | |
| 10 mg | $71 | In Stock | |
| 25 mg | $143 | In Stock | |
| 50 mg | $218 | In Stock | |
| 100 mg | $328 | In Stock | |
| 200 mg | $467 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $47 | In Stock |
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Purity:99.89%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Epothilone A (Epo A) is a microtubule-stabilizing agent with EC0.01 of 2 μM. |
| Targets&IC50 | Tubulin:2 μM(EC0.01) |
| In vivo | Epothilone A induces microtubule polymerization, causing cell cycle arrest at the G2-M phase, and exhibits cytotoxicity, as well as induces apoptosis. It effectively inhibits the proliferation of HCT116 cells with an IC50 of 4.4 nM. Epothilone A possesses cytotoxicity against KB3-1, KBV-1, Hela, and Hs578T cells with IC50 values ranging from 13 nM to 160 nM. Additionally, Epothilone A competitively binds to microtubules against paclitaxel, with an IC50 of 2.3 μM. |
| Kinase Assay | Tubulin polymerization assay: Samples for electron microscopy are placed on carbon-over-Parlodion-coated grids (300 mesh) and negatively stained with 2% uranyl acetate. Microtubule assembly in the presence or absence of Epothilone A is monitored spectrophotometrically by using a spectrophotometer equipped with a thermostatically regulated liquid circulator. The temperature is held at 35 °C and changes in turbidity (representative of polymer mass) are monitored at 350 nm. Effective concentration (EC0.01), defined as the interpolated concentration capable of inducing an initial slope of 0.01 OD/min rate, is calculated using the formula EC0.01 = concentration/slope. |
| Cell Research | Cell lines: KB3-1,KBV-1,Hela,and Hs578T cells. Concentrations: 0–2 μM. Method: cells are plated either in 48-well plates (for trypan blue and cell counting) or onto coverslips.After 24 hours,cells are treated with Epothilone A and are scored at regular intervals.For the cytotoxicity analysis,cells are counted and scored as trypan blue positive or negative. |
| Alias | epothile, Epo A |
| Molecular Weight | 493.66 |
| Formula | C26H39NO6S |
| Cas No. | 152044-53-6 |
| Smiles | C[C@H]1CCC[C@H]2O[C@H]2C[C@H](OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@H]1O)C(\C)=C\c1csc(C)n1 |
| Relative Density. | 1.143g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 92 mg/mL (186.4 mM) DMSO: 92 mg/mL (186.4 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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