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GDC-0623

Catalog No. T6843Cas No. 1168091-68-6
Alias RG 7421, MEK inhibitor 1, GDC0623, G-868

GDC-0623 (RG 7421) is a potent, ATP-uncompetitive MEK1 inhibitor with a Ki of 0.13 nM, currently in Phase 1.

GDC-0623

GDC-0623

Purity: 98.95%
Catalog No. T6843Alias RG 7421, MEK inhibitor 1, GDC0623, G-868Cas No. 1168091-68-6
GDC-0623 (RG 7421) is a potent, ATP-uncompetitive MEK1 inhibitor with a Ki of 0.13 nM, currently in Phase 1.
Pack SizePriceAvailabilityQuantity
1 mg$48In Stock
2 mg$67In Stock
5 mg$122In Stock
10 mg$197In Stock
25 mg$295In Stock
50 mg$388In Stock
100 mg$645In Stock
1 mL x 10 mM (in DMSO)$122In Stock
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Purity:98.95%
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Product Introduction

Bioactivity
Description
GDC-0623 (RG 7421) is a potent, ATP-uncompetitive MEK1 inhibitor with a Ki of 0.13 nM, currently in Phase 1.
Targets&IC50
MEK1:0.13 nM(ki)
AliasRG 7421, MEK inhibitor 1, GDC0623, G-868
Chemical Properties
Molecular Weight456.21
FormulaC16H14FIN4O3
Cas No.1168091-68-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 5 mg/mL (11 mM)
DMSO: 91 mg/mL (198.82 mM), Heating is recommended.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.1920 mL10.9599 mL21.9197 mL109.5986 mL
5 mM0.4384 mL2.1920 mL4.3839 mL21.9197 mL
10 mM0.2192 mL1.0960 mL2.1920 mL10.9599 mL
DMSO
1mg5mg10mg50mg
20 mM0.1096 mL0.5480 mL1.0960 mL5.4799 mL
50 mM0.0438 mL0.2192 mL0.4384 mL2.1920 mL
100 mM0.0219 mL0.1096 mL0.2192 mL1.0960 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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